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Found 94 with Last Name = 'priepke' and Initial = 'hw'
TargetCoagulation factor X(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  20nM ΔG°:  -45.7kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  40nM ΔG°:  -43.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi:  57nM ΔG°:  -43.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  67nM ΔG°:  -42.6kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  102nM ΔG°:  -41.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi:  110nM ΔG°:  -41.3kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi:  140nM ΔG°:  -40.7kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  780nM ΔG°:  -36.3kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  4.10E+3nM ΔG°:  -32.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  6.50E+3nM ΔG°:  -30.8kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi:  6.80E+3nM ΔG°:  -30.7kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  8.20E+3nM ΔG°:  -30.2kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi:  9.00E+3nM ΔG°:  -30.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  9.20E+3nM ΔG°:  -29.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  1.30E+4nM ΔG°:  -29.0kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi:  1.60E+4nM ΔG°:  -28.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi: >3.00E+4nM ΔG°: >-26.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi: >4.00E+4nM ΔG°: >-26.1kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi:  4.40E+4nM ΔG°:  -25.9kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17295(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Affinity DataKi: >5.00E+4nM ΔG°: >-25.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17297(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Affinity DataKi: >5.00E+4nM ΔG°: >-25.5kJ/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129964(1-[2-(4-Carbamimidoyl-phenoxy)-4-methyl-quinolin-7...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129977(4-[7-(1,1-Dimethyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129957(2-[2-(4-Carbamimidoyl-phenoxy)-4-methyl-quinolin-7...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129954(4-(4-Methyl-7-o-tolyl-quinolin-2-yloxy)-benzamidin...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129957(2-[2-(4-Carbamimidoyl-phenoxy)-4-methyl-quinolin-7...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129968(4-[7-(1,1-Dimethyl-2-oxo-2-piperidin-1-yl-ethyl)-4...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129976(4-{4-Methyl-3-oxo-7-[1-(pyrrolidine-1-carbonyl)-cy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129956(CHEMBL74314 | {3-[2-(4-Carbamimidoyl-phenoxy)-4-me...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129967(2-[2-(4-Carbamimidoyl-phenoxy)-4-methyl-quinolin-7...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129973(2-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-d...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129965(CHEMBL73043 | {3-[2-(4-Carbamimidoyl-phenoxy)-4-me...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129979(4-{7-[1,1-Dimethyl-2-(3-methyl-piperidin-1-yl)-2-o...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129974(4-{7-[1-(2-Hydroxymethyl-pyrrolidine-1-carbonyl)-c...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129969(CHEMBL74263 | N-{1-[3-(4-Carbamimidoyl-benzyl)-1-m...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129958(3-[2-(4-Carbamimidoyl-phenoxy)-4-methyl-quinolin-7...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129972(2-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-d...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129961(4-(4-Methyl-7-p-tolyl-quinolin-2-yloxy)-benzamidin...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129970(1-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-d...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129964(1-[2-(4-Carbamimidoyl-phenoxy)-4-methyl-quinolin-7...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129953(4-(4-Methyl-7-o-tolyl-quinolin-2-ylamino)-benzamid...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129963(4-(7-Bromo-4-methyl-quinolin-2-yloxy)-benzamidine ...)
Affinity DataIC50:  66nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129975(4-[7-(1,1-Dimethyl-2-oxo-2-piperazin-1-yl-ethyl)-4...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129976(4-{4-Methyl-3-oxo-7-[1-(pyrrolidine-1-carbonyl)-cy...)
Affinity DataIC50:  84nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129966(4-(7-Bromo-4-methyl-quinolin-2-ylamino)-benzamidin...)
Affinity DataIC50:  87nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129962(CHEMBL310265 | [2-(4-Carbamimidoyl-phenoxy)-4-meth...)
Affinity DataIC50:  92nMAssay Description:In vitro inhibitory activity against thrombin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM50129978(CHEMBL76068 | [(1-{1-[3-(4-Carbamimidoyl-benzyl)-1...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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