Found 72 Enz. Inhib. hit(s) with all data for entry = 50017739 
Affinity DataIC50: 4.96E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as a substrate preincubated for 10 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 7.72E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as a substrate preincubated for 10 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as a substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as a substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: 1.98E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as a substrate preincubated for 10 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: 2.99E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as a substrate preincubated for 10 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.06E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: 3.78E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as a substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as a substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as a substrate preincubated for 10 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as a substrate preincubated for 10 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as a substrate preincubated for 10 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as a substrate preincubated for 10 mins followed by NADPH addition and measured afte...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition and measured after 1...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 470nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation preincubated with M372049 for 15 mins followed by compound treat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 8.64E+3nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation preincubated with M372049 for 15 mins followed by compound treat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 360nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation preincubated with M372049 for 15 mins followed by compound treat...More data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 3.20E+4nMAssay Description:Displacement of Flu-P19 probe from human NPR-C (27 to 541 residues) by fluorescence polarization analysisMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 3.27E+5nMAssay Description:Displacement of Flu-P19 probe from human NPR-C (27 to 541 residues) by fluorescence polarization analysisMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 6.00E+4nMAssay Description:Displacement of Flu-P19 probe from human NPR-C (27 to 541 residues) by fluorescence polarization analysisMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 970nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 2.22E+4nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 860nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 3.45E+3nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 390nMAssay Description:Agonist activity at NPRC in rat small mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 1.43E+3nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 6.20E+3nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 1.55E+4nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 7.81E+4nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 6.24E+3nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 1.02E+5nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 4.43E+3nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
TargetAtrial natriuretic peptide receptor 3(Rattus norvegicus)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataEC50: 3.76E+3nMAssay Description:Agonist activity at NPRC in rat aorta assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.16E+3nMAssay Description:Agonist activity at NPRC in wild type mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.58E+3nMAssay Description:Agonist activity at NPRC in wild type mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.51E+3nMAssay Description:Agonist activity at NPRC in wild type mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.64E+3nMAssay Description:Agonist activity at NPRC in knock out mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.01E+4nMAssay Description:Agonist activity at NPRC in knock out mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.02E+3nMAssay Description:Agonist activity at NPRC in knock out mouse mesenteric arteries assessed as vasorelaxation by Organ bath assayMore data for this Ligand-Target Pair
