Compile Data Set for Download or QSAR
maximum 50k data
Found 104 Enz. Inhib. hit(s) with all data for entry = 11273
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604304(US11661422, Example 10)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604307(US11661422, Example 11)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604307(US11661422, Example 11)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604308(4-(9-(4-methoxyphenyl)-4-methyl-8-(4-((4-(methylsu...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604308(4-(9-(4-methoxyphenyl)-4-methyl-8-(4-((4-(methylsu...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604309(US11661422, Example 13)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604309(US11661422, Example 13)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604313(4-(2-(tert-Butyl)-4- methyl-8-(4-((4- (methylsulfo...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604313(4-(2-(tert-Butyl)-4- methyl-8-(4-((4- (methylsulfo...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604313(4-(2-(tert-Butyl)-4- methyl-8-(4-((4- (methylsulfo...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604313(4-(2-(tert-Butyl)-4- methyl-8-(4-((4- (methylsulfo...)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604314(9-(4-(4-Acetylpiperazin- 1-yl)phenyl)-2-(tert- but...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604314(9-(4-(4-Acetylpiperazin- 1-yl)phenyl)-2-(tert- but...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604314(9-(4-(4-Acetylpiperazin- 1-yl)phenyl)-2-(tert- but...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604314(9-(4-(4-Acetylpiperazin- 1-yl)phenyl)-2-(tert- but...)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604316(US11661422, Example 20)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604316(US11661422, Example 20)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604317(4-(9-(4-(1- Aminocyclopropyl) phenyl)-4-methyl-8-(...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604317(4-(9-(4-(1- Aminocyclopropyl) phenyl)-4-methyl-8-(...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604318(4-(4-Methyl-9-(1- methyl-1H-pyrrol-3-yl)- 8-(4-((4...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604318(4-(4-Methyl-9-(1- methyl-1H-pyrrol-3-yl)- 8-(4-((4...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604319(4-(9-Cyclopropyl-4- methyl-8-(4-((4- (methylsulfon...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604319(4-(9-Cyclopropyl-4- methyl-8-(4-((4- (methylsulfon...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604321(US11661422, Example 25)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604321(US11661422, Example 25)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604253(US11661422, Example 1)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604253(US11661422, Example 1)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604254(US11661422, Example 2)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604254(US11661422, Example 2)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604258(US11661422, Example 3)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604258(US11661422, Example 3)
Affinity DataIC50: <100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604269(US11661422, Example 5)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604269(US11661422, Example 5)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [826-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604287(4-(8-(4-((4-(methylsulfonyl)piperidin-1- yl)methyl...)
Affinity DataIC50: <100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604287(4-(8-(4-((4-(methylsulfonyl)piperidin-1- yl)methyl...)
Affinity DataIC50: <100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604304(US11661422, Example 10)
Affinity DataIC50:  300nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604322(US11661422, Example 26)
Affinity DataIC50:  300nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM604297(US11661422, Example 9)
Affinity DataIC50:  300nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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