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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50287572
Substrate
n/a
Meas. Tech.
ChEMBL_1729728 (CHEMBL4145006)
IC50
4640±n/a nM
Citation
 Brant, MG; Goodwin-Tindall, J; Stover, KR; Stafford, PM; Wu, F; Meek, AR; Schiavini, P; Wohnig, S; Weaver, DF Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold. ACS Med Chem Lett 9:131-136 (2018) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50287572
Synonyms:
CHEMBL4164194 | US11572354, Compound 10g
Type:
Small organic molecule
Emp. Form.:
C18H14FN3O
Mol. Mass.:
307.3217
SMILES:
Oc1cccc(c1)-c1cncn1Cc1cc2cc(F)ccc2[nH]1
Structure:
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