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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50423179
Substrate
n/a
Meas. Tech.
ChEMBL_447921 (CHEMBL898171)
IC50
832±n/a nM
Citation
 Bonger, KM; van den Berg, RJ; Heitman, LH; IJzerman, AP; Oosterom, J; Timmers, CM; Overkleeft, HS; van der Marel, GA Synthesis and evaluation of homo-bivalent GnRHR ligands. Bioorg Med Chem 15:4841-56 (2007) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50423179
Synonyms:
CHEMBL236222
Type:
Small organic molecule
Emp. Form.:
C48H57F2N13O9
Mol. Mass.:
998.0447
SMILES:
CCNC(=O)Nc1ccc(cc1)-c1nc2n(Cc3c(F)cccc3F)cc(C(=O)OCC)c(=O)n2c1CN(CC(=O)NCc1cn(CCOCCOCCOCCOCCN=[N+]=[N-])nn1)Cc1ccccc1
Structure:
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