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Target
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Ligand
BDBM50204290
Substrate
n/a
Meas. Tech.
ChEMBL_1627213 (CHEMBL3869734)
IC50
226±n/a nM
Citation
 Lam, B; Arikawa, Y; Cramlett, J; Dong, Q; de Jong, R; Feher, V; Grimshaw, CE; Farrell, PJ; Hoffman, ID; Jennings, A; Jones, B; Matuszkiewicz, J; Miura, J; Miyake, H; Natala, SR; Shi, L; Takahashi, M; Taylor, E; Wyrick, C; Yano, J; Zalevsky, J; Nie, Z Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg Med Chem Lett 26:5947-5950 (2016) [PubMed]  Article 
Target
Name:
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Synonyms:
PHKG2 | PHKG2_HUMAN | Phosphorylase kinase | Phosphorylase kinase gamma subunit 2
Type:
PROTEIN
Mol. Mass.:
46440.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774277
Residue:
406
Sequence:
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
  
Inhibitor
Name:
BDBM50204290
Synonyms:
CHEMBL3979920 | US11077111, Compound IIIa | US20230295171, Example 102
Type:
Small organic molecule
Emp. Form.:
C17H21FN6O
Mol. Mass.:
344.3866
SMILES:
Cn1cc(cn1)-c1nc(N[C@@H]2CCCC[C@@H]2N)c(F)c2CNC(=O)c12 |r|
Structure:
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