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Target
Serine/threonine-protein kinase PAK 4
Ligand
BDBM50204290
Substrate
n/a
Meas. Tech.
ChEMBL_1627211 (CHEMBL3869732)
IC50
76±n/a nM
Citation
Lam, B; Arikawa, Y; Cramlett, J; Dong, Q; de Jong, R; Feher, V; Grimshaw, CE; Farrell, PJ; Hoffman, ID; Jennings, A; Jones, B; Matuszkiewicz, J; Miura, J; Miyake, H; Natala, SR; Shi, L; Takahashi, M; Taylor, E; Wyrick, C; Yano, J; Zalevsky, J; Nie, Z Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg Med Chem Lett 26:5947-5950 (2016) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein kinase PAK 4
Synonyms:
KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:
Protein
Mol. Mass.:
64098.01
Organism:
Homo sapiens (Human)
Description:
O96013
Residue:
591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR