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Report error Found 512 of affinity data for UniProtKB/TrEMBL: O00750
LigandPNGBDBM288368(US10087187, Compound 59)
Affinity DataKd:  0.100nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM444320(US10660898, Example 70)
Affinity DataIC50: 0.200nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM288369(US10087187, Compound 60)
Affinity DataKd:  0.200nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
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Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM444306(US10660898, Example 25)
Affinity DataIC50: 0.251nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM288380(US10087187, Compound 73)
Affinity DataKd:  0.300nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
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Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM50200978(CHEMBL3956037 | US10087187, Compound 58)
Affinity DataKd:  0.400nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
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Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM50308135(PKI-587 | 1-(4-{[4-(Dimethylamino)piperidin-1-yl]c...)
Affinity DataKd:  0.460nMAssay Description:Binding affinity to human PI3KC2beta (M1 to L1634 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandPNGBDBM288376(US10087187, Compound 67)
Affinity DataKd:  0.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
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Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288384(US10087187, Compound 84 | US10087187, Compound 79)
Affinity DataKd:  0.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataKd:  0.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288320(US10087187, Compound 13)
Affinity DataKd:  0.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM444315(US10660898, Example 53)
Affinity DataIC50: 0.501nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM288352(US10087187, Compound 42)
Affinity DataKd:  0.600nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM444311(US10660898, Example 39)
Affinity DataIC50: 0.631nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM288366(US10087187, Compound 57)
Affinity DataKd:  0.700nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288390(US10087187, Compound 85)
Affinity DataKd:  0.700nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288403(US10087187, Compound 104)
Affinity DataKd:  0.700nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM50579668(CHEMBL5091438)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of PIK3C2B (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM288384(US10087187, Compound 84 | US10087187, Compound 79)
Affinity DataKd:  0.800nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288364(US10087187, Compound 56 | US10087187, Compound 55)
Affinity DataKd:  0.900nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288346(US10087187, Compound 36)
Affinity DataKd:  0.900nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM444301(US10660898, Example 15)
Affinity DataIC50: 1nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM444319(US10660898, Example 63)
Affinity DataIC50: 1nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM489258(US10961236, Example 31 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PIK3C2B (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM288395(US10087187, Compound 91)
Affinity DataKd:  1.10nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288310(US10087187, Compound 3)
Affinity DataKd:  1.10nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288349(US10087187, Compound 39)
Affinity DataKd:  1.10nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288321(US10087187, Compound 14 | US10087187, Compound 14a...)
Affinity DataKd:  1.20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM50200972(CHEMBL3974658 | US10087187, Compound 22)
Affinity DataKd:  1.20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288364(US10087187, Compound 56 | US10087187, Compound 55)
Affinity DataKd:  1.20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288404(US10087187, Compound 105)
Affinity DataKd:  1.20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288321(US10087187, Compound 14 | US10087187, Compound 14a...)
Affinity DataKd:  1.20nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM444314(US10660898, Example 50)
Affinity DataIC50: 1.26nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM288381(US10087187, Compound 74 | US10087187, Compound 77 ...)
Affinity DataKd:  1.30nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM50200930(CHEMBL3928423 | US10087187, Compound 66)
Affinity DataKd:  1.30nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288387(US10087187, Compound 82)
Affinity DataKd:  1.30nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288359(US10087187, Compound 50)
Affinity DataKd:  1.30nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288321(US10087187, Compound 14 | US10087187, Compound 14a...)
Affinity DataKd:  1.30nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288381(US10087187, Compound 74 | US10087187, Compound 77 ...)
Affinity DataKd:  1.40nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
Affinity DataKd:  1.40nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM50200969(CHEMBL3970860 | US10087187, Compound 9)
Affinity DataKd:  1.40nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288354(US10087187, Compound 44)
Affinity DataKd:  1.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288319(US10087187, Compound 12)
Affinity DataKd: <1.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288321(US10087187, Compound 14 | US10087187, Compound 14a...)
Affinity DataKd:  1.5nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM444297(US10660898, Example 5)
Affinity DataIC50: 1.58nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM444312(US10660898, Example 41)
Affinity DataIC50: 1.58nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM444321(US10660898, Example 72)
Affinity DataIC50: 1.58nMAssay Description:PI3Kinase Reaction Buffer was prepared by diluting the stock 1:4 with de-ionized water. Freshly prepared DTT was added at a final concentration of 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2021
Entry Details
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LigandPNGBDBM288398(US10087187, Compound 97)
Affinity DataKd:  1.60nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
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Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288357(US10087187, Compound 48)
Affinity DataKd:  1.70nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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LigandPNGBDBM288342(US10087187, Compound 32)
Affinity DataKd:  1.80nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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