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Found 109 for UniProtKB: P35349
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50004051(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Affinity DataKi:  398nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM86201(L-homocysteine sulfinic acid)
Affinity DataKi:  6.17E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50220147((S)-2-amino-4-sulfobutanoic acid | CHEMBL230951 | ...)
Affinity DataKi:  7.94E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM85473(L-Cysteic acid, 8 | L-cysteic acid)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM86194(CAS_109 | L-cysteine sulfinic acid | NSC_109)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1/2/3/4/5/6/7/8(Rattus norvegicus)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity for rat 5-hydroxytryptamine 2A receptor using [3H]-DOBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1/2/3/4/5/6/7/8(Rattus norvegicus)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50136493(1-Methyl-4,9-dihydro-3H-beta-carboline | 1-methyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1/2/3/4/5/6/7/8(Rattus norvegicus)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50132104(6-Methoxy-1-methyl-4,9-dihydro-3H-beta-carboline |...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataIC50:  1.14E+3nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataIC50:  2.06E+3nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50291680((S)-2-(4-Phosphono-phenylamino)-propionic acid | C...)
Affinity DataIC50:  4.80E+5nMAssay Description:Antagonistic activity of the compound against Metabotropic glutamate receptor 6 was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM82006(D-AP4 | D-APB | US9212196, L-AP4)
Affinity DataEC50:  1.03E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  4.20E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196907(US9212196, Derivative 3)
Affinity DataEC50:  4.70E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196908(US9212196, Derivative 4)
Affinity DataEC50:  9.00E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196909(US9212196, Derivative 5)
Affinity DataEC50:  5.95E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196914(US9212196, Derivative 10)
Affinity DataEC50:  1.84E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196915(US9212196, Derivative 11)
Affinity DataEC50:  3.80E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196917(US9212196, Derivative 13)
Affinity DataEC50:  5.40E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196932(US9212196, Derivative 28)
Affinity DataEC50:  2.50E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM196934(US9212196, Derivative 30)
Affinity DataEC50:  1.30E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50017269(CHEMBL3287724 | US10099993, Compound 73)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50022759(CHEMBL3298273)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu6 receptor expressed in HEK293 cells assessed as glutamate-induced GIRK channel-mediated thallium f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50069348((S)-2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Affinity DataEC50: >1.00E+6nMAssay Description:Antagonistic activity against rat (mGluR) metabotropic glutamate receptor 6 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50069349((S)-2-Amino-2-benzyl-3-(3,5-dioxo-[1,2,4]oxadiazol...)
Affinity DataEC50: >1.00E+6nMAssay Description:Antagonistic activity against rat (mGluR) metabotropic glutamate receptor 6 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50:  55nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50034503((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Affinity DataEC50:  4.00E+4nMAssay Description:Metabotropic glutamate receptor 6 antagonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  3.60E+3nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50138784((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Affinity DataEC50:  147nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50034504((1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Affinity DataEC50:  600nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50004881((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...)
Affinity DataEC50:  4.70E+3nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50138781((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...)
Affinity DataEC50:  1.20E+3nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50:  3.45E+3nMAssay Description:Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50088290(CHEMBL3427499)
Affinity DataEC50:  6.01E+3nMAssay Description:Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataEC50:  8.22E+4nMAssay Description:Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50:  3.78E+5nMAssay Description:Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50060137((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Affinity DataEC50:  1.84E+4nMAssay Description:Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50:  2.08E+3nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50174527((S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric...)
Affinity DataEC50: >5.00E+5nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50220009(CHEMBL241972 | L-(+)-2-amino-4-[(hydroxy)phosphiny...)
Affinity DataEC50:  2.78E+4nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50220011(CHEMBL243925 | L-(+)-2-amino-4-thiophosphonobutyri...)
Affinity DataEC50:  730nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50134443(CHEMBL3746457)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM66976((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid;...)
Affinity DataEC50:  6.00E+4nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50071161((2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxy...)
Affinity DataEC50:  2.00E+4nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50291320((2R,4R)-4-Benzoylamino-pyrrolidine-2,4-dicarboxyli...)
Affinity DataEC50:  1.00E+6nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50052398((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Affinity DataEC50:  1.10E+5nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50004051(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Affinity DataEC50:  1.00E+3nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In DepthDetails Article
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