Compile Data Set for Download or QSAR
maximum 50k data
Found 90 of affinity data for UniProtKB/TrEMBL: P49019
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataIC50:  3.00E+3nMAssay Description:Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325913(2-(3-(2-chlorophenoxy)propoxy)pyrido[2,3-d]pyrimid...)
Affinity DataIC50:  3.30E+4nMAssay Description:Displacement of radioligand from human GPR109BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325899(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Affinity DataIC50: >5.00E+4nMAssay Description:Displacement of radioligand from human GPR109BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50325922(2-((4-fluorophenethyloxy)methyl)pyrido[2,3-d]pyrim...)
Affinity DataIC50: >5.00E+4nMAssay Description:Displacement of radioligand from human GPR109BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220833(5-(5-propyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL...)
Affinity DataEC50:  724nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220853(5-(5-cyclopropyl-1H-pyrazol-3-yl)-1H-tetrazole | C...)
Affinity DataEC50:  3.23E+3nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23515(CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-ni...)
Affinity DataEC50:  7.59E+4nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220842(3-butyl-1H-pyrazole-5-carboxylic acid | 5-butyl-1H...)
Affinity DataEC50:  1.17E+4nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50211363(3-isopropyl-1H-pyrazole-5-carboxylic acid | 5-Isop...)
Affinity DataEC50:  4.17E+4nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50216551(3-pentyl-1H-pyrazole-5-carboxylic acid | 5-butylpy...)
Affinity DataEC50:  1.86E+4nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220833(5-(5-propyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL...)
Affinity DataEC50:  724nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220853(5-(5-cyclopropyl-1H-pyrazol-3-yl)-1H-tetrazole | C...)
Affinity DataEC50:  3.23E+3nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220834(5-(5-butyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL3...)
Affinity DataEC50:  7.59E+3nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50220835(5-(5-ethyl-4-fluoro-1H-pyrazol-3-yl)-1H-tetrazole ...)
Affinity DataEC50:  1.23E+4nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  4.20E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208112(5-cyclopent-1-enyl-5-methyl-4-oxo-4,5-dihydro-fura...)
Affinity DataEC50:  5.10E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208137((+)-5-(5-bromo-thiophen-3-yl)-5-methyl-4-oxo-4,5-d...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208135((+)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-...)
Affinity DataEC50:  180nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208113(5-(4-fluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro-fur...)
Affinity DataEC50:  9.90E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208116(5-(5-chloro-thiophen-2-yl)-5-methyl-4-oxo-4,5-dihy...)
Affinity DataEC50:  3.70E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208140(5-methyl-5-(5-methyl-thiophen-2-yl)-4-oxo-4,5-dihy...)
Affinity DataEC50:  270nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208126(5-(3,5-difluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro...)
Affinity DataEC50:  3.30E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208125(5-ethyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxy...)
Affinity DataEC50:  4.80E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208110(5-methyl-5-(4-bromo-thiophen-2-yl)-4-oxo-4,5-dihyd...)
Affinity DataEC50:  4.10E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208124(5-(3-ethyl-phenyl)-5-methyl-4-oxo-4,5-dihydro-fura...)
Affinity DataEC50:  6.20E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208141(5-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-4,5-di...)
Affinity DataEC50:  1.26E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208121(5-(2,4-difluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro...)
Affinity DataEC50:  2.40E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208128(5-(3,4-difluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro...)
Affinity DataEC50:  1.90E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208123(5-(2,6-difluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro...)
Affinity DataEC50:  3.60E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208134(5-methyl-5-(4-methyl-thiophen-2-yl)-4-oxo-4,5-dihy...)
Affinity DataEC50:  1.80E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208114(5-(3-chloro-phenyl)-5-methyl-4-oxo-4,5-dihydro-fur...)
Affinity DataEC50:  2.20E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208127(5-(4-bromo-5-methyl-thiophen-2-yl)-5-methyl-4-oxo-...)
Affinity DataEC50:  1.04E+4nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208115((+)-5-(3-bromo-phenyl)-5-methyl-4-oxo-4,5-dihydro-...)
Affinity DataEC50:  4.90E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208139(5-methyl-4-oxo-5-thiophen-3-yl-4,5-dihydro-furan-2...)
Affinity DataEC50:  4.20E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208120(5-(3-iodo-phenyl)-5-methyl-4-oxo-4,5-dihydro-furan...)
Affinity DataEC50:  5.10E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208122((+)-5-(5-chloro-thiophen-3-yl)-5-methyl-4-oxo-4,5-...)
Affinity DataEC50:  1.70E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414492(CHEMBL564914)
Affinity DataEC50:  14nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414490(CHEMBL550153)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414491(CHEMBL559204)
Affinity DataEC50:  141nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414500(CHEMBL557298)
Affinity DataEC50:  5.62E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414498(CHEMBL550563)
Affinity DataEC50:  8.71E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414502(CHEMBL561720)
Affinity DataEC50:  3.98E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414513(CHEMBL394468)
Affinity DataEC50:  42nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414494(CHEMBL564300)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414504(CHEMBL560254)
Affinity DataEC50:  8.32E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414499(CHEMBL561920)
Affinity DataEC50:  851nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414495(CHEMBL562675)
Affinity DataEC50:  257nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414505(CHEMBL552399)
Affinity DataEC50:  6.76E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414506(CHEMBL553415)
Affinity DataEC50:  4.47E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 3(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50414493(CHEMBL565055)
Affinity DataEC50:  8.91E+3nMAssay Description:Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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