Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) for PDB: 1R5K
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataEC50:  390nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataEC50:  390nMAssay Description:Induction of ERalpha degradation in human MCF7 cells in phenol red free RPMI medium containing 5% charcoal-stripped FBS incubated for 4 hrs by IRDye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Fluormone-ES2 binding affinity to ERalpha (unknown origin) after 2 hrs by fluorescent polarization based competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to ER alpha (unknown origin) by LanthaScreen TR-FRET competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 39nMAssay Description:Displacement of [3H]17-beta-estradiol from human Estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 264nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 18 to 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 654nMAssay Description:Antagonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 1.27E+3nMAssay Description:Suppression of ER alpha in human MCF7 cells after 24 hrs by immunostaining analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 1.29E+3nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at ER alpha in human MCF7 cells assessed as inhibition of estradiol-induced PR expression treated for 24 hrs after incubation wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 1.28E+4nMAssay Description:Antagonist activity at ERalpha in human MCF7 cells assessed as inhibition of estrogen-induced transcription preincubated overnight followed by estrog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Seragon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041611((E)-3-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenyl]-acr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at ER alpha in human MCF7 cells assessed as PR gene expression after 24 hrs by laser scanning imaging cytometer analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)