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Found 140 with Last Name = 'chang' and Initial = 'ct'
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  14nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010241(CHEMBL1234672)
Affinity DataKi:  29nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010236(CHEMBL3144200)
Affinity DataKi:  39nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50000038(CHEMBL3228321)
Affinity DataKi:  40nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010239(CHEMBL1236538)
Affinity DataKi:  190nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50404974(5-NITRO-DUMP | CHEMBL2051758)
Affinity DataKi:  500nMAssay Description:Inactivation of thymidylate synthetase measured asKi at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027919(5-fluoro-deoxyuridinemonophosphate | CHEMBL416879)
Affinity DataKi:  500nMAssay Description:Inactivation of thymidylate synthetase measured asKi at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010240(CHEMBL3246102)
Affinity DataKi:  550nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010238(CHEMBL1160593)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010242(CHEMBL1160594)
Affinity DataKi:  1.60E+3nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027920(5-quinonyl-deoxyuridinemonophosphate | CHEMBL8016)
Affinity DataKi:  2.00E+3nMAssay Description:Inactivation of thymidylate synthetase measured asKi at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50000019(CHEMBL3144338)
Affinity DataKi:  2.80E+3nMAssay Description:Competitive inhibition of Lactobacillus casei thymidylate synthetase using dTMP as substrate assessed as release of water after 15 mins by double rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50404975(CHEMBL2051976)
Affinity DataKi:  4.00E+3nMAssay Description:Inactivation of thymidylate synthetase measured as Ki at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50000019(CHEMBL3144338)
Affinity DataKi:  1.00E+5nMAssay Description:Competitive inhibition of Lactobacillus casei thymidylate synthetase using 2'-deoxy[5-3H]uridine-5'-phosphate as substrate assessed as release of wat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50000034(CHEMBL3228124)
Affinity DataKi:  1.50E+5nMAssay Description:Competitive inhibition of Lactobacillus casei thymidylate synthetase using 2'-deoxy[5-3H]uridine-5'-phosphate as substrate assessed as release of wat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033030((R)-3-{2-[(R)-2-Oxo-3-(2-piperidin-4-yl-ethyl)-pip...)
Affinity DataIC50: >5nMAssay Description:Inhibition of human umbilical vein endothelial cell adhesion to fibronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033030((R)-3-{2-[(R)-2-Oxo-3-(2-piperidin-4-yl-ethyl)-pip...)
Affinity DataIC50: >5nMAssay Description:Inhibition of human umbilical vein endothelial cell adhesion to fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033030((R)-3-{2-[(R)-2-Oxo-3-(2-piperidin-4-yl-ethyl)-pip...)
Affinity DataIC50: >5nMAssay Description:Inhibition of human umbilical vein endothelial cell adhesion to vitronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
TargetProtein kinase C zeta type(Rattus norvegicus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039593((S)-3-[4-(4-Piperidin-4-yl-butoxy)-phenyl]-2-(thio...)
Affinity DataIC50:  15nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004071((S)-2-Phenylmethanesulfonylamino-3-[4-(4-piperidin...)
Affinity DataIC50:  18nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039590((S)-2-Benzenesulfonylamino-3-[4-(4-piperidin-4-yl-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039592((S)-3-[4-(4-Piperidin-4-yl-butoxy)-phenyl]-2-(prop...)
Affinity DataIC50:  23nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039580((S)-2-(2-Phenyl-ethanesulfonylamino)-3-[4-(4-piper...)
Affinity DataIC50:  29nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004061((S)-2-Hexanoylamino-3-[4-(4-piperidin-4-yl-butoxy)...)
Affinity DataIC50:  35nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039576((S)-2-((E)-2-Phenyl-ethenesulfonylamino)-3-[4-(4-p...)
Affinity DataIC50:  43nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039572((S)-2-Pentanoylamino-3-[4-(4-piperidin-4-yl-butoxy...)
Affinity DataIC50:  47nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039591((S)-2-Methanesulfonylamino-3-[4-(4-piperidin-4-yl-...)
Affinity DataIC50:  63nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039595((S)-2-(3-Phenyl-propionylamino)-3-[4-(4-piperidin-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039570((S)-3-[4-(4-Piperidin-4-yl-butoxy)-phenyl]-2-propi...)
Affinity DataIC50:  105nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039569((S)-3-(Butane-1-sulfonylamino)-4-[4-(4-piperidin-4...)
Affinity DataIC50:  140nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039586((S)-2-Benzyloxycarbonylamino-3-[4-((E)-4-piperidin...)
Affinity DataIC50:  240nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004060((S)-2-Benzyloxycarbonylamino-3-[4-(4-piperidin-4-y...)
Affinity DataIC50:  260nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Rattus norvegicus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50217039(CHEMBL420938)
Affinity DataIC50:  300nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50431178(CHEMBL2332562)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039588((S)-2-Benzyloxycarbonylamino-3-[4-(4-piperazin-1-y...)
Affinity DataIC50:  500nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039597((S)-2-Acetylamino-3-[4-(4-piperidin-4-yl-butoxy)-p...)
Affinity DataIC50:  500nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039568((S)-3-(Butane-1-sulfonylamino)-4-[4-(3-piperidin-4...)
Affinity DataIC50:  600nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039601((4S,7R,13R,16S)-16-Acetylamino-7-carboxymethyl-13-...)
Affinity DataIC50:  680nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Rattus norvegicus)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50217036(CHEMBL74983)
Affinity DataIC50:  700nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004065((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-(butane-1-su...)
Affinity DataIC50:  780nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039584((R)-2-(Butane-1-sulfonylamino)-3-[4-(4-piperidin-4...)
Affinity DataIC50:  800nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039577((S)-3-Benzyloxycarbonylamino-4-[4-(3-piperidin-4-y...)
Affinity DataIC50:  880nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039571((S)-2-Benzyloxycarbonylamino-3-[4-(5-piperazin-1-y...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50431179(CHEMBL2332561)
Affinity DataIC50:  1.17E+3nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039581((S)-2-Hexanoylamino-3-[4-(5-piperidin-4-yl-pentyl)...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxoeicosanoid receptor 1(Homo sapiens (Human))
Florida Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50431184(CHEMBL2332567)
Affinity DataIC50:  1.55E+3nMAssay Description:Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50039573(2-[1-[1-amino-4-amino(imino)methylamino-(1S)-butyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004066((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-phenylmethan...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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