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Found 102 with Last Name = 'groppi' and Initial = 've'
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377050(CHEMBL403858 | PH-709829)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190793(CHEMBL268939 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377049(CHEMBL258031)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190791(CHEMBL210865 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190789(CHEMBL208565 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377048(CHEMBL403857)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377050(CHEMBL403858 | PH-709829)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  12.5nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377047(CHEMBL404299)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190784(CHEMBL378496 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377051(CHEMBL256578)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377053(CHEMBL258239)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161753(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  27nMAssay Description:Inhibition of methyllycaconitine (MLA) binding to Nicotinic acetylcholine receptor alpha-7 in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377052(CHEMBL257145)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190790(CHEMBL214195 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190794(CHEMBL211572 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  174nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  188nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  310nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50377050(CHEMBL403858 | PH-709829)
Affinity DataKi:  350nMAssay Description:Binding affinity to rat 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  511nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  580nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  628nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  630nMAssay Description:Binding affinity to rat 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  663nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  962nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  1.66E+3nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161753(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.66E+3nMAssay Description:Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor from rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  4.54E+3nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50525013(CHEMBL4476440 | US11401286, Example 81)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50248919((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524997(CHEMBL4570605 | US11401286, Example 58)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50248919((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human His6-tagged PDE4D2 expressed in baculovirus infected Sf9 insect cells using cAMP as substrate preincubated for 5 to 1...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50525005(CHEMBL4459298 | US11401286, Example 171)
Affinity DataIC50:  43nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524998(CHEMBL4564798 | US11401286, Example 62)
Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524991(CHEMBL4544243 | US11401286, Example 57)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50525009(CHEMBL4437670 | US11401286, Example 191)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50525003(CHEMBL4449185 | US11401286, Example 182)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50525000(CHEMBL4561428 | US11401286, Example 120)
Affinity DataIC50:  98nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50525006(CHEMBL4434783 | US11401286, Example 80)
Affinity DataIC50:  105nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524994(CHEMBL4541964 | US11401286, Example 142)
Affinity DataIC50:  127nMAssay Description:Inhibition of recombinant human His6-tagged PDE4D2 expressed in baculovirus infected Sf9 insect cells using cAMP as substrate preincubated for 5 to 1...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50524995(CHEMBL4593524 | US11401286, Example 195)
Affinity DataIC50:  128nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Tetra Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50525004(CHEMBL4553222 | US11401286, Example 3)
Affinity DataIC50:  136nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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