Found 195 with Last Name = 'rottmann' and Initial = 'm' TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 7.70nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 10.2nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 30.8nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program
Curated by ChEMBL
Affinity DataKi: 55.6nMAssay Description:Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of PMX in Plasmodium falciparum 3D7 HA epitopeMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 11nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of Plasmodium falciparum recombinant C-terminal TEV cleavable 8his-tagged PMX by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 133nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 142nMAssay Description:Inhibition of Plasmodium falciparum PMIX by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 142nMAssay Description:Inhibition of PMIX in Plasmodium falciparum 3D7 HA epitopeMore data for this Ligand-Target Pair
Affinity DataIC50: 165nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 168nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 172nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 172nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 186nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 186nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumMore data for this Ligand-Target Pair
Affinity DataIC50: 189nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 202nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 226nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of Plasmodium falciparum PMIX by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 268nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 312nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 323nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assayMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 388nMAssay Description:Inhibitory activity against Herpes simplex virus type-I specific thymidine kinaseMore data for this Ligand-Target Pair
