Compile Data Set for Download or QSAR
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Found 32 Enz. Inhib. hit(s) with all data for entry = 50014054
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataKi:  700nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataKi:  800nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataKi:  900nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572159(CHEMBL1489870)
Affinity DataKi:  900nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572160(CHEMBL1452107)
Affinity DataKi:  2.50E+3nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50:  530nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50:  870nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572159(CHEMBL1489870)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572160(CHEMBL1452107)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human 15-LOX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human 15-LOX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human 15-LOX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX8(Mus musculus)
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of mouse 15-LOX2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX8(Mus musculus)
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of mouse 15-LOX2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX8(Mus musculus)
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of mouse 15-LOX2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human 5-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human 5-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human 5-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human 12-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human 12-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human 12-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataEC50:  3.10E+4nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataEC50:  750nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572160(CHEMBL1452107)
Affinity DataEC50:  600nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed