Found 12 Enz. Inhib. hit(s) with Target = 'Sodium/hydrogen exchanger 1' and Ligand = 'BDBM50058759' TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 30.7nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of NHE1-mediated rat platelet swellingMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of NHE1 in rat platelets by Platelet swelling assayMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibitory concentration against human sodium/hydrogen exchanger (NHE-1) in PS120 variant cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human NHE1 expressed in PS120 cells assessed as imposed acidosisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
