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Found 38 Enz. Inhib. hit(s) with all data for entry = 50033406
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50344685(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat SGLT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344669(6,8-dichloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344680(4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-tri...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50344681(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of rat SGLT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344679(4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-1,2,4-tri...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344678(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-propyl-4H-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344685(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344675(6-chloro-4-((5-(5-chloropyridin-2-yl)-4-(3,3,3-tri...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344676(6-chloro-8-nitro-4-((5-(5-(trifluoromethyl)pyridin...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344666(4-((5-(benzyloxymethyl)-4-(3,3,3-trifluoropropyl)-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344683(6,8-dimethyl-4-((5-((1R,2R)-2-phenylcyclopropyl)-4...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344670(6,8-dichloro-4-((5-(2-methylthiazol-4-yl)-4-(3,3,3...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344684((R)-6,8-dimethyl-4-((4-propyl-5-(1,2,3,4-tetrahydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344671(CHEMBL1779219 | rac-6,8-dichloro-4-((5-(2-phenylcy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344681(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344673(6,8-dichloro-4-((5-(2,3-dihydro-1H-inden-2-yl)-4-(...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344668(6,8-dichloro-4-((5-(pyridin-2-yl)-4-(3,3,3-trifluo...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344672(CHEMBL1779220 | rac-6,8-dichloro-4-((5-(1,2,3,4-te...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344690(CHEMBL1779207 | N-(6-chloro-4-((5-(4-chloropheneth...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344691(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344667(6,8-dichloro-4-((5-(4-chlorophenyl)-4-(3,3,3-trifl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344688(8-amino-6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344674(6-chloro-8-nitro-4-((5-(pyridin-2-yl)-4-(3,3,3-tri...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344686(CHEMBL1779203 | methyl 6-chloro-4-((5-(4-chlorophe...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344692(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344665(6,8-dichloro-4-((5-((4-chlorophenoxy)methyl)-4-(3,...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344694(CHEMBL1779211 | rac-6,8-dichloro-4-((5-(2-phenylpr...)
Affinity DataIC50:  89nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344677(6-chloro-3-oxo-4-((5-(pyridin-2-yl)-4-(3,3,3-trifl...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344695(6,8-dichloro-4-((5-(2-methyl-2-phenylpropyl)-4-(3,...)
Affinity DataIC50:  480nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344693(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344682(6-chloro-4-((5-(3-methylpyridin-2-yl)-4-propyl-4H-...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340013(6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-tr...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344689(CHEMBL1779206 | N-(6-chloro-4-((5-(4-chloropheneth...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344687(6-chloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-triflu...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-Glucose uptake using [14C]-methyl glucopyranoside after 60 mins by m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344681(6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344685(4-((5-(2,3-dihydro-1H-inden-2-yl)-4-propyl-4H-1,2,...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed