BDBM50322535 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide::3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide::CHEMBL1171837::PONATINIB::US10464902, Ponatinib::US9255107, AP24534

SMILES: Cc1ccc(cc1C#Cc2cnc3n2nccc3)C(=O)Nc4ccc(c(c4)C(F)(F)F)CN5CCN(CC5)C

InChI Key: InChIKey=PHXJVRSECIGDHY-UHFFFAOYSA-N

Data: 1 KI  133 IC50  4 Kd  6 EC50

PDB links: 15 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 144 hits for monomerid = 50322535   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
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Putative glycogen synthase kinase 3 alpha (Corn smut fungus)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [229-512] (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src [251-533] (Chicken)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527] (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,I2020T] (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.0500	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM50322535 (3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair