The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.6M data for 1.1M Compounds and 8.9K Targets. Of those, 1,154K data for 533K Compounds and 4.4K Targets were curated by BindingDB curators.

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Recently Added Targets

    1. Lys-gingipain, Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561), B2RLK2 (Curated 08/21/22), kgp: 99 subμM ligands
    2. Neuraminidase, Influenza A virus (strain A/WS/1933 H1N1), B4URF0 (Curated 08/24/22), NA: 12 subμM ligands
    3. Polymerase basic protein 2, Influenza A virus (strain A/WS/1933 H1N1), B4URF7 (Curated 08/06/22), PB2: 345 subμM ligands
    4. Hsp90 chaperone protein kinase-targeting subunit, Filobasidiella neoformans, F5H9H0 (Curated 08/06/22), : 93 subμM ligands
    5. Beta-hexosaminidase, Bovine, H7BWW2 (Curated 08/24/22), HEXB: 7 subμM ligands
    6. Hydroxyacid oxidase 1, Pig, I3LVF1 (Curated 08/22/22), HAO1: 1 subμM ligands
    7. Stanniocalcin-1, Mouse, O55183 (Curated 08/25/22), Stc1: 3 subμM ligands
    8. Proteinase-activated receptor 4, Mouse, O88634 (Curated 08/24/22), F2rl3: 12 subμM ligands
    9. Immunoglobulin lambda variable 6-57, Human, P01721 (Curated 08/23/22), IGLV6-57: 25 subμM ligands
    10. Envelope phospholipase F13, VACV, P04021 (Curated 08/24/22), : 5 subμM ligands
    11. Eukaryotic translation initiation factor 2 subunit 1, Human, P05198 (Curated 08/20/22), EIF2S1: 21 subμM ligands
    12. Replicase polyprotein 1a, 2019-nCoV, P0DTC1 (Curated 08/15/22), : 134 subμM ligands
    13. Calcitonin gene-related peptide 2, Human, P10092 (Curated 08/20/22), CALCB: 23 subμM ligands
    14. Islet amyloid polypeptide, Human, P10997 (Curated 08/23/22), IAPP: 4 subμM ligands
    15. Alpha-1-antitrypsin-related protein, Human, P20848 (Curated 08/24/22), SERPINA2: 1 subμM ligands
    16. Lon protease homolog, mitochondrial, Human, P36776 (Curated 08/20/22), LONP1: 20 subμM ligands
    17. Sterol regulatory element-binding protein 1, Human, P36956 (Curated 08/20/22), SREBF1: 2 subμM ligands
    18. Heat shock protein 90 homolog, Yeast, P46598 (Curated 08/06/22), HSP90: 37 subμM ligands
    19. Dual specificity mitogen-activated protein kinase kinase 4, Mouse, P47809 (Curated 08/19/22), Map2k4: 4 subμM ligands
    20. Stanniocalcin-1, Human, P52823 (Curated 08/25/22), STC1: 3 subμM ligands
    21. Tyrosine-protein kinase receptor UFO, Mouse, Q00993 (Curated 08/21/22), Axl: 32 subμM ligands
    22. Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Rat, Q09326 (Curated 08/25/22), Mgat2: 3 subμM ligands
    23. Gastric inhibitory polypeptide receptor, Mouse, Q0P543 (Curated 08/18/22), Gipr: 2 subμM ligands
    24. Beta-hexosaminidase subunit alpha, Bovine, Q0V8R6 (Curated 08/24/22), HEXA: 1 subμM ligands
    25. E3 ubiquitin-protein ligase CBL-B, Human, Q13191 (Curated 08/20/22), CBLB: 1 subμM ligands
    26. Glycine N-methyltransferase, Human, Q14749 (Curated 08/24/22), GNMT: 5 subμM ligands
    27. Transient receptor potential cation channel subfamily M member 1, Mouse, Q2TV84 (Curated 08/23/22), Trpm1: 1 subμM ligands
    28. Serine/threonine-protein kinase TNNI3K, Mouse, Q5GIG6 (Curated 08/24/22), Tnni3k: 1 subμM ligands
    29. Tyrosine-protein kinase, Rat, Q5S255 (Curated 08/20/22), Btk: 1 subμM ligands
    30. Tyrosine-protein kinase Mer, Mouse, Q60805 (Curated 08/21/22), Mertk: 30 subμM ligands
    31. N6-adenosine-methyltransferase catalytic subunit, Human, Q86U44 (Curated 08/22/22), METTL3: 6 subμM ligands
    32. Hepatitis A virus cellular receptor 2, Human, Q8TDQ0 (Curated 08/25/22), HAVCR2: 10 subμM ligands
    33. Three-prime repair exonuclease 1, Mouse, Q91XB0 (Curated 08/01/22), Trex1: 16 subμM ligands
    34. Mitogen-activated protein kinase 8, Mouse, Q91Y86 (Curated 08/24/22), Mapk8: 8 subμM ligands
    35. F-box/WD repeat-containing protein 5, Human, Q969U6 (Curated 08/07/22), FBXW5: 23 subμM ligands
    36. Proline-rich acidic protein 1, Human, Q96NZ9 (Curated 08/23/22), PRAP1: 6 subμM ligands
    37. Protein orai-2, Human, Q96SN7 (Curated 08/23/22), ORAI2: 1 subμM ligands
    38. Bifunctional polynucleotide phosphatase/kinase, Human, Q96T60 (Curated 08/15/22), PNKP: 66 subμM ligands
    39. Calcium and integrin-binding protein 1, Human, Q99828 (Curated 08/22/22), CIB1: 25 subμM ligands
    40. Carboxypeptidase B2, Rat, Q9EQV9 (Curated 08/23/22), Cpb2: 2 subμM ligands
    41. Serine/threonine-protein kinase/endoribonuclease IRE1, Mouse, Q9EQY0 (Curated 08/19/22), Ern1: 1 subμM ligands
    42. Presenilins-associated rhomboid-like protein, mitochondrial, Human, Q9H300 (Curated 08/22/22), PARL: 2 subμM ligands
    43. Pannexin-1, Mouse, Q9JIP4 (Curated 08/23/22), Panx1: 3 subμM ligands
    44. Transient receptor potential cation channel subfamily M member 5, Mouse, Q9JJH7 (Curated 08/20/22), Trpm5: 4 subμM ligands
    45. Probable G-protein coupled receptor 27, Human, Q9NS67 (Curated 08/23/22), GPR27: 8 subμM ligands
    46. Three-prime repair exonuclease 1, Human, Q9NSU2 (Curated 08/01/22), TREX1: 26 subμM ligands
    47. Apelin receptor, Mouse, Q9WV08 (Curated 08/24/22), Aplnr: 23 subμM ligands

Coronavirus Binding Data

BindingDB has accelerated collection of COVID related data. You can find the result here.

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BindingDB Data Curation

BindingDB curates US Patents. We have scanned patents back to 2013 for suitable data and are currently up to date as of mid-2020. However, we cannot be sure of capturing all relevant patents, so if you know of a useful one we have missed, please let us know and we will try to curate it. As of August 28, 2022, BindingDB's patent dataset comprises:

  1. Patents: 5,866
  2. Binding measurements: 904,846
  3. Compounds: 437,875
  4. Target proteins: 2,321
  5. Assays: 8,481
  6. Average Number of Targets per Patent: 1.91

BindingDB curates a set of journals not covered by other public databases. As of August 28, 2022, the status of this curation effort is as follows:

BindingDB is supported by NIH's National Institute of General Medical Sciences (GM070064), and is located at the Skaggs School of Pharmacy and Pharmaceutical Sciences of the University of California San Diego