Patent: (prefix with "US" like US6078908)
  1. Patent
    Data
    Cmpds
    HGNC*
    Patent Title
    Organization
    Deposition
    Downloads
  2. 98
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte Corporation; Incyte Holdings Corporation
    08/18/23
  3. 364
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer Inc.
    08/18/23
  4. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    GENUV Inc.
    08/18/23
  5. 36
    Compounds and methods of use
    Medivation Technologies LLC
    08/18/23
  6. 2
    Crystalline hydrate of a JAK inhibitor compound
    Theravance Biopharma R&D IP, LLC
    08/18/23
  7. 34
    ENPP1 inhibitors and their use for the treatment of cancer
    THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    08/18/23
  8. 647
    Methods, compositions, and uses of novel FYN kinase inhibitors
    Pathways Neuro Pharma, Inc.
    08/18/23
  9. 42
    Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
    D. E. Shaw Research, LLC; Relay Therapeutics, Inc.
    08/18/23
  10. 94
    Pyrazolyl derivatives useful as anti-cancer agents
    NOVARTIS AG
    08/18/23
  11. 34
    Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
    REVOLUTION MEDICINES, INC.
    08/18/23
  12. 143
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent GmbH
    08/18/23
  13. 365
    SOS1 inhibitors
    MIRATI THERAPEUTICS, INC.
    08/18/23
  14. 9
    Substituted bicyclic compounds
    Bristol-Myers Squibb Company
    08/18/23
  15. 303
    Thiadiazole IRAK4 inhibitors
    Gilead Sciences, Inc.
    08/18/23
  16. 79
    Agent enhancing antitumor effect using pyrazolo[3,4-d]pyrimidine compound
    TAIHO PHARMACEUTICAL CO., LTD.
    08/11/23
  17. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent GmbH
    08/11/23
  18. 42
    Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors
    Eil Therapeutics, Inc.
    08/11/23
  19. 264
    Fused pyrimidine pyridinone compounds as JAK inhibitors
    THERAVANCE BIOPHARMA R&D IP, LLC
    08/11/23
  20. 318
    Substituted benzamides
    Hoffmann-La Roche Inc.
    08/11/23
  21. 15
    2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    08/06/23
  22. 234
    6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Ajax Therapeutics, Inc.
    08/06/23
  23. 44
    Compound having KDM5 inhibitory activity and pharmaceutical use thereof
    ONO PHARMACEUTICAL CO., LTD.
    08/06/23
  24. 82
    Cyclic ether derivatives of pyrazolo[1,5-A]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International GmbH
    08/06/23
  25. 80
    Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
    INVENTISBIO CO., LTD.
    08/06/23
  26. 101
    Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Board of Regents, The University of Texas System
    08/06/23
  27. 93
    Isoindoline compositions and methods for treating neurodegenerative disease
    Cognition Therapeutics, Inc.
    08/06/23
  28. 21
    Isoquinoline-steroid conjugates and uses thereof
    Aerie Pharmaceuticals, Inc.
    08/06/23
  29. 25
    MAGL inhibitors
    H. LUNDBECKA/S
    08/06/23
  30. 25
    Macrocyclic immunomodulators
    CHEMOCENTRYX, INC.
    08/06/23
  31. 51
    Macrocyclic indoles as Mcl-1 inhibitors
    ASCENTAGE PHARMA (SUZHOU) CO., LTD.; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; ASCENTAGE PHARMA GROUP CORP LIMITED
    08/06/23
  32. 1
    Method for preparing pyrrolidinyl urea derivative
    ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD.
    08/06/23
  33. 24
    Naphthyridinone compounds as JAK2 V617F inhibitors
    Incyte Corporation
    08/06/23
  34. 51
    Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
    ASTRAZENECA AB
    08/06/23
  35. 96
    Pyridazinones as PARP7 inhibtors
    Ribon Therapeutics, Inc.
    08/06/23
  36. 217
    Therapeutic compounds and compositions
    EXITHERA PHARMACEUTICALS, INC.
    08/06/23
  37. 121
    ATM kinase inhibitors and compositions and methods of use thereof
    CHDI Foundation, Inc.
    07/31/23
  38. 106
    Azalactam compounds as HPK1 inhibitors
    PFIZER INC.
    07/31/23
  39. 82
    C5a receptor modulators
    IDORSIA PHARMACEUTICALS LTD.
    07/31/23
  40. 123
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics Incorporated
    07/31/23
  41. 14
    Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
    OcuTerra Therapeutics, Inc.
    07/31/23
  42. 245
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    07/31/23
  43. 491
    MYST family histone acetyltransferase inhibitors
    Epizyme, Inc.
    07/31/23
  44. 24
    Pyridinone MK2 inhibitors and uses thereof
    XINTHERA, INC.
    07/31/23
  45. 385
    Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
    Dart Neuroscience, LLC
    07/31/23
  46. 138
    Bicycloheptane pyrrolidine orexin receptor agonists
    Merck Sharp & Dohme LLC
    07/25/23
  47. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    AstraZeneca AB
    07/25/23
  48. 22
    Compounds and compositions as protein kinase inhibitors
    ARRAY BIOPHARMA INC.
    07/25/23
  49. 55
    Compounds useful as RET inhibitors
    Cancer Research Technology Limited
    07/25/23
  50. 82
    MK2 inhibitors and uses thereof
    XINTHERA, INC.
    07/25/23
  51. 2
    Methods of treating disorders using CSF1R inhibitors
    Deciphera Pharmaceuticals, LLC
    07/25/23
  52. 16
    Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors
    Mekanistic Therapeutics LLC
    07/19/23
  53. 155
    5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
    Bristol-Myers Squibb Company
    07/16/23
  54. 40
    Amino pyrimidine derivatives
    Novartis AG
    07/16/23
  55. 17
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche Inc.
    07/16/23
  56. 88
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics Incorporated
    07/16/23
  57. 35
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    AstraZeneca AB
    07/16/23
  58. 11
    Compounds for the treatment of kinase-dependent disorders
    Exelixis, Inc.
    07/16/23
  59. 51
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    07/16/23
  60. 13
    Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
    Great Novel Therapeutics Biotech & Medicals Corporation
    07/16/23
  61. 96
    Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
    Incyte Corporation
    07/16/23
  62. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    BioSplice Therapeutics, Inc.
    07/16/23
  63. 12
    Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
    Foresee Pharmaceuticals Co., Inc.
    07/16/23
  64. 21
    Pharmaceutical compounds
    SAREUM LIMITED
    07/16/23
  65. 82
    Polycyclic compounds as allosteric SHP2 inhibitors
    REVOLUTION MEDICINES, INC.
    07/16/23
  66. 159
    Pyridone amides as modulators of sodium channels
    VERTEX PHARMACEUTICALS INCORPORATED
    07/16/23
  67. 7
    Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs
    Olema Pharmaceuticals, Inc.
    07/16/23
  68. 50
    4-substitued cytisine analogues
    TBA
    07/09/23
  69. 7
    Antibody-drug conjugates comprising a cyclic dinucleotide
    Takeda Pharmaceutical Company Limited
    07/09/23
  70. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    07/09/23
  71. 36
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    AstraZeneca AB
    07/09/23
  72. 378
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica NV
    07/09/23
  73. 56
    FGFR4 inhibitor, preparation method therefor, and applications thereof
    Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
    07/09/23
  74. 11
    Fused imidazo-piperidine JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    07/09/23
  75. 148
    Granzyme B directed imaging and therapy
    CytoSite Biopharma Inc.
    07/09/23
  76. 65
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    07/09/23
  77. 204
    MCL1 inhibitors
    Gilead Sciences, Inc.
    07/09/23
  78. 97
    Methods of treating intraocular pressure with activators of Tie-2
    EyePoint Pharmaceuticals, Inc.
    07/09/23
  79. 80
    RIP1K inhibitors
    Rigel Pharmaceuticals, Inc.
    07/09/23
  80. 206
    Therapeutically active compounds and their methods of use
    Servier Pharmaceuticals LLC
    07/09/23
  81. 86
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology Limited
    07/03/23
  82. 496
    Imidazole-containing inhibitors of ALK2 kinase
    BioCryst Pharmaceuticals, Inc.
    07/03/23
  83. 18
    Tetrazole derivatives as TRPA1 inhibitors
    Boehringer Ingelheim International GmbH
    07/03/23
  84. 8
    Thienopyrrole compounds
    Gilead Sciences, Inc.
    07/03/23
  85. 26
    Tricyclic urea compounds as JAK2 V617F inhibitors
    Incyte Corporation
    07/03/23
  86. 54
    Benzimidazole derivative compounds and uses thereof
    Pfizer Inc.
    07/02/23
  87. 13
    MASP-2 inhibitors and methods of use
    OMEROS CORPORATION
    07/02/23
  88. 129
    Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
    CHRONOS THERAPEUTICS LIMITED
    07/02/23
  89. 28
    Treatment of Rett syndrome
    Cold Spring Harbor Laboratory
    07/02/23
  90. 87
    Tricyclic compounds as histone methyltransferase inhibitors
    Global Blood Therapeutics, Inc.
    07/02/23
  91. 170
    ALK2 inhibitors and methods for inhibiting BMP signaling
    The Brigham and Women''s Hospital, Inc.; The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
    06/26/23
  92. 4
    Aminopyrimidinyl derivatives
    Pfizer Inc.
    06/26/23
  93. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    AstraZeneca AB
    06/26/23
  94. 32
    Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy of Sciences
    06/26/23
  95. 4
    Glucagon-like peptide1 receptor agonists
    Eli Lilly and Company
    06/26/23
  96. 23
    Indolizine derivatives and their application in medicine
    KIND PHARMACEUTICAL
    06/26/23
  97. 252
    Pyrazole MAGL inhibitors
    H. LUNDBECK A/S
    06/26/23
  98. 32
    Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
    HOFFMANN-LA ROCHE INC.; EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
    06/26/23
  99. 6
    Substituted piperazines as BTK inhibitors
    HUTCHISON MEDIPHARMA LIMITED
    06/26/23
  100. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly and Company
    06/19/23
  101. 98
    Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
    Petra Pharma Corporation
    06/19/23
  102. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    06/19/23
  103. 81
    C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
    The United States of America, as represented by the Secretary, Department of Health and Human Services; Pontificia Universidad Catolica de Chile
    06/19/23
  104. 18
    Compound as mTOR inhibitor and use thereof
    MEDICINAL BIOCONVERGENCE RESEARCH CENTER; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    06/19/23
  105. 18
    Halo-allylamine SSAO/VAP-1 inhibitor and use thereof
    NANJING TRANSTHERA BIOSCIENCES CO., LTD.
    06/19/23
  106. 663
    Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same
    1ST Biotherapeutics, Inc.
    06/19/23
  107. 113
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    ESTEVE PHARMACEUTICALS, S.A.
    06/19/23
  108. 2
    Pan-tropic entry inhibitors
    Emory University
    06/19/23
  109. 14
    Pyrazolochlorophenyl compounds, compositions and methods of use thereof
    Genentech, Inc.
    06/19/23
  110. 50
    Selective androgen receptor degrader (SARD) ligands and methods of use
    University of Tennessee Research Foundation
    06/19/23
  111. 111
    Substituted 4-phenylpiperidines, their preparation and use
    THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    06/19/23
  112. 228
    Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition
    Optikira LLC; The Regents of the University of California
    06/19/23
  113. 814
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma Inc.
    06/19/23
  114. 327
    Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
    Kumquat Biosciences Inc.
    06/19/23
  115. 2
    5-HT2A agonists for use in treatment of depression
    LOPHORA APS
    06/11/23
  116. 156
    BRD4-kinase inhibitors as cancer therapeutics
    H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    06/11/23
  117. 8
    Compounds for degrading Tau protein aggregates and uses thereof
    APRINOIA THERAPEUTICS LIMITED
    06/11/23
  118. 9
    Derivatives of 4-aminoantipyrine as anti-Alzheimers butyrylcholinesterase inhibitors
    TBA
    06/11/23
  119. 11
    GLP-1 receptor agonist and use thereof
    ILDONG PHARMACEUTICAL CO., LTD.
    06/11/23
  120. 443
    MCL-1 inhibitors
    Gilead Sciences, Inc.
    06/11/23
  121. 10
    Polypeptide compound, pharmaceutical composition, preparation method and application thereof
    CHENGDU SINTANOVO BIOTECHNOLOGY CO., LTD.
    06/11/23
  122. 31
    Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors
    G1 Therapeutics, Inc.
    06/11/23
  123. 46
    Substituted benzene compounds
    Epizyme, Inc.
    06/11/23
  124. 144
    Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof
    Japan Tobacco Inc.
    06/11/23
  125. 155
    Amino acid compounds and methods of use
    Pliant Therapeutics, Inc.
    06/02/23
  126. 192
    Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
    H. Lundbeck A/S
    06/02/23
  127. 78
    Compounds for the treatment of BRAF-associated diseases and disorders
    Array BioPharma Inc.
    06/02/23
  128. 18
    Diazaindole derivative and use thereof as CHK1 inhibitor
    MEDSHINE DISCOVERY INC.
    06/02/23
  129. 12
    Dimethyl amino azetidine amides as JAK inhibitors
    THERAVANCE BIOPHARMA R&D IP, LLC
    06/02/23
  130. 48
    Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
    TBA
    06/02/23
  131. 103
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC
    06/02/23
  132. 124
    Pharmaceutical compounds
    PFIZER INC.
    06/02/23
  133. 93
    Pyrazoles
    JANSSEN PHARMACEUTICALS, INC.
    06/02/23
  134. 22
    Selective estrogen receptor degraders
    Eli Lilly and Company
    06/02/23
  135. 53
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer Inc.
    06/02/23
  136. 99
    Substituted amino triazoles useful as chitinase inhibitors
    Molecure S.A.
    06/02/23
  137. 14
    Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors
    LUOXIN PHARMACEUTICAL (SHANGHAI) CO., LTD.; SHANDONG LUOXIN PHARMACEUTICAL GROUP STOCK CO., LTD.; MEDSHINE DISCOVERY INC.
    06/02/23
  138. 17
    6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
    Sprint Bioscience AB
    06/01/23
  139. 21
    Compounds and methods useful for treating or preventing cancers
    THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.
    06/01/23
  140. 253
    Compounds which are inhibitors of Notum
    UCL Business LTD
    06/01/23
  141. 9
    Method for controlling hematophagous or sap-feeding arthropods
    Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    06/01/23
  142. 313
    Opioid receptor modulators
    EPIODYNE, INC.
    06/01/23
  143. 90
    Selective D3 dopamine receptor agonists and methods of their use
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; THE UNIVERSITY OF KANSAS; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    06/01/23
  144. 19
    Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor
    SUMITOMO PHARMA CO., LTD.
    06/01/23
  145. 260
    Sulfonamide compound or salt thereof
    Taiho Pharmaceutial Co., Ltd.
    06/01/23
  146. 14
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly and Company
    05/27/23
  147. 39
    Lymphoid-specific tyrosine phosphatase (LYP) inhibitors
    Purdue Research Foundation
    05/27/23
  148. 111
    SHP2 phosphatase inhibitors and methods of use thereof
    D. E. Shaw Research, LLC; Relay Therapeutics, Inc.
    05/27/23
  149. 46
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity
    PRAXIS PRECISION MEDICINES, INC.
    05/27/23
  150. 57
    Substituted pyridine derivatives as SARM1 inhibitors
    NURA BIO, INC.
    05/27/23
  151. 32
    Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
    SHIONOGI & CO., LTD.
    05/27/23
  152. 21
    Triazolo-pyrimidine compounds and uses thereof
    Dizal (Jiangsu) Pharmaceutical Co., Ltd.
    05/27/23
  153. 223
    Indole carboxamide compounds
    Bristol-Myers Squibb Company
    05/22/23
  154. 2
    Method of treatment with histamine-3 receptor inverse agonist
    SUVEN LIFE SCIENCES LIMITED
    05/22/23
  155. 4
    Protein degraders and uses thereof
    KYMERA THERAPEUTICS, INC.
    05/22/23
  156. 15
    Spirocyclic compounds
    C4 Therapeutics, Inc.
    05/22/23
  157. 19
    Uracil compound as c-MET/AXL inhibitor
    MEDSHINE DISCOVERY, INC.
    05/22/23
  158. 20
    6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Purdue Research Foundation
    05/11/23
  159. 1532
    Aminopyrrolotriazines as kinase inhibitors
    Bristol-Myers Squibb Company
    05/11/23
  160. 186
    Benzoimidazoles as prolyl hydroxylase inhibitors
    Janssen Pharmaceutica NV
    05/11/23
  161. 18
    Compounds active towards nuclear receptors
    NUEVOLUTION A/S
    05/10/23
  162. 19
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    05/10/23
  163. 36
    Oxysterols and methods of use thereof
    SAGE THERAPEUTICS, INC.
    05/10/23
  164. 83
    Substituted pyridotriazine compounds and uses thereof
    Gilead Sciences, Inc.
    05/10/23
  165. 24
    3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof
    SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
    05/09/23
  166. 302
    8-aminoisoquinoline compounds and uses thereof
    Genentech, Inc.
    05/09/23
  167. 116
    Enzyme inhibitors
    KalVista Pharmaceuticals Limited
    05/09/23
  168. 123
    Glycosidase inhibitors
    Asceneuron SA
    05/09/23
  169. 167
    Inhibitors of RHO associated coiled-coil containing protein kinase
    Kadmon Corporation, LLC
    05/09/23
  170. 10
    Pharmaceutical formulations comprising CCR3 antagonists
    Alkahest, Inc.
    05/09/23
  171. 62
    Substituted condensed thiophenes as modulators of sting
    CTXT PTY LIMITED
    05/09/23
  172. 22
    Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase
    INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    05/05/23
  173. 106
    Bicyclic amide compounds and methods of use thereof
    Genentech, Inc.
    05/05/23
  174. 9
    Curcumin analogues as zinc chelators and their uses
    THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK; CHEM-MASTER INTERNATIONAL INC.
    05/05/23
  175. 42
    FGFR4 inhibitor and preparation method and use thereof
    Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
    05/05/23
  176. 40
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    05/05/23
  177. 138
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent GmbH
    05/05/23
  178. 161
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
    05/05/23
  179. 93
    Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
    Hoffmann-La Roche Inc.
    05/05/23
  180. 5
    PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
    H. Lundbeck A/S
    05/05/23
  181. 19
    Compounds and therapeutic uses thereof
    VioGen Biosciences, LLC
    04/30/23
  182. 64
    MTORC1 modulators and uses thereof
    Aeovian Pharmaceuticals, Inc.
    04/30/23
  183. 285
    PCSK9 inhibitors and methods of use thereof
    AstraZeneca AB
    04/30/23
  184. 34
    Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
    Array BioPharma Inc.
    04/30/23
  185. 19
    Compounds and compositions for the treatment of parasitic diseases
    Novartis AG
    04/23/23
  186. 53
    Cyclic dinucleotides as sting agonists
    Janssen Biotech, Inc.
    04/23/23
  187. 10
    Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)
    THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    04/23/23
  188. 26
    JAK1 pathway inhibitors for the treatment of gastrointestinal disease
    Incyte Corporation
    04/23/23
  189. 427
    Monoacylglycerol lipase modulators
    Janssen Pharmaceutica NV
    04/23/23
  190. 20
    PD-L1/STING conjugates and methods of use
    Incyte Corporation
    04/23/23
  191. 4
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    MINDSET PHARMA INC.
    04/23/23
  192. 3
    SHP2 inhibitor compositions and methods for treating cancer
    Revolution Medicines, Inc.
    04/23/23
  193. 719
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    04/23/23
  194. 28
    Benzamide compounds
    Recurium IP Holdings, LLC
    04/14/23
  195. 26
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Corporation
    04/14/23
  196. 13
    Bipyrazole derivatives as JAK inhibitors
    Incyte Corporation
    04/14/23
  197. 27
    Certain chemical compositions and methods of use thereof
    Algen Biotechnologies, Inc.
    04/14/23
  198. 164
    Compounds, compositions, and methods
    Denali Therapeutics Inc.
    04/14/23
  199. 46
    Heterocyclic compound, application thereof and pharmaceutical composition comprising same
    SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.
    04/14/23
  200. 26
    Highly active CSF1R inhibitor compound
    XIAMEN BIOTIME BIOTECHNOLOGY CO., LTD.
    04/14/23
  201. 25
    Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof
    HINOVA PHARMACEUTICALS INC.
    04/14/23
  202. 40
    Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof
    STINGRAY THERAPEUTICS, INC.
    04/14/23
  203. 73
    Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof
    Pharmablock Sciences (Nanjing), Inc.
    04/14/23
  204. 14
    Oxazolidinone antibiotic compounds and process of preparation
    BUGWORKS RESEARCH, INC.
    04/14/23
  205. 99
    PARP1 inhibitors and uses thereof
    XINTHERA, INC.
    04/14/23
  206. 3
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma Inc.
    04/14/23
  207. 144
    Pyrrolotriazine compounds as TAM inhibitors
    Incyte Corporation
    04/14/23
  208. 51
    Small molecule inducers of autophagy
    Board of Regents, The University of Texas System
    04/14/23
  209. 514
    Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
    D. E. Shaw Research, LLC; Relay Therapeutics, Inc.
    04/14/23
  210. 4
    Amino alcohol derivative, pharmaceutical composition and application thereof
    BEIJING FORELAND PHARMA CO., LTD.
    04/09/23
  211. 15
    Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
    SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
    04/09/23
  212. 6
    Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
    STEALTH BIOTHERAPEUTICS INC.
    04/09/23
  213. 13
    Dash inhibitors, and uses related thereto
    Trustees of Tufts College
    04/09/23
  214. 165
    Dihydrothieno[3,2-b]pyridine compounds
    IDEAYA BIOSCIENCES, INC.
    04/09/23
  215. 33
    Heterocyclic compounds as BET inhibitors
    NUVATION BIO INC.
    04/09/23
  216. 27
    Inhibitors of EGFR and methods of use thereof
    Dana-Farber Cancer Institute, Inc.
    04/09/23
  217. 479
    MASP-2 inhibitors and methods of use
    OMEROS CORPORATION
    04/09/23
  218. 22
    Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
    Heptares Therapeutics Limited
    04/09/23
  219. 57
    RIP1K inhibitors
    Rigel Pharmaceuticals, Inc.
    04/09/23
  220. 2
    Solid forms of a plasma kallikrein inhibitor and salts thereof
    KalVista Pharmaceuticals Limited
    04/09/23
  221. 80
    Spirocyclic compounds
    C4 Therapeutics, Inc.
    04/09/23
  222. 225
    Substituted pyridopyrimidinonyl compounds useful as T cell activators
    TBA
    04/09/23
  223. 145
    Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
    VENENUM BIODESIGN, LLC
    04/09/23
  224. 73
    Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International GmbH
    04/09/23
  225. 21
    Compounds useful as immunomodulators
    Bristol-Myers Squibb Company
    03/31/23
  226. 227
    Condensed ring compounds having dopamine D3 receptor antagonistic effect
    Shionogi & Co., Ltd.
    03/31/23
  227. 289
    Fluoroalkyl-oxadiazoles and uses thereof
    Tenaya Therapeutics, Inc.
    03/31/23
  228. 22
    Heterocyclic RIP1 inhibitory compounds
    Rigel Pharmaceuticals, Inc.
    03/31/23
  229. 3
    Heterocyclic compounds for inhibiting TYK2 activities
    Beijing Innocare Pharma Tech Co.
    03/31/23
  230. 20
    Inhibiting mutant IDH-1
    FORMA Therapeutics, Inc.
    03/31/23
  231. 282
    Inhibitors of LRRK2 kinase
    HALIA THERAPEUTICS, INC.
    03/31/23
  232. 72
    Spiro-oxazolones
    Hoffmann-La Roche Inc.
    03/31/23
  233. 64
    Therapeutic agent for non-motor symptoms associated with Parkinson's disease
    Sumitomo Pharma Co., Ltd.
    03/31/23
  234. 23
    Thienopyrimidones
    Boehringer Ingelheim International GmbH
    03/31/23
  235. 29
    Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof
    Beijing Innocare Pharma Tech Co., Ltd.
    03/26/23
  236. 44
    Antibacterial agents: arylalkylcarboxamido phloroglucinols
    RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    03/26/23
  237. 4
    BRD4 inhibitor
    HINOVA PHARMACEUTICALS INC.
    03/26/23
  238. 14
    Cyanoaryl-aniline compounds for treatment of dermal disorders
    NFLECTION THERAPEUTICS, INC.
    03/26/23
  239. 40
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    03/26/23
  240. 26
    Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof
    University Health Network
    03/26/23
  241. 171
    Inhibitors of histone deacetylase
    The General Hospital Corporation; The Broad Institute, Inc.; Massachusetts Institute of Technology
    03/26/23
  242. 452
    N-cyano-7-azanorbornane derivatives and uses thereof
    AMGEN INC.
    03/26/23
  243. 38
    Pyrazine compounds and uses thereof
    DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.
    03/26/23
  244. 73
    Pyrrolo[1,2-b]pyridazine derivatives
    Gilead Sciences, Inc.
    03/26/23
  245. 69
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Corporation
    03/20/23
  246. 4
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    03/20/23
  247. 2
    Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)
    FORMA Therapeutics, Inc.
    03/20/23
  248. 39
    5-heteroaryl-1H-pyrazol-3-amine derivative
    Sumitomo Pharma Co., Ltd.
    03/19/23
  249. 158
    5-membered heteroaryl carboxamide compounds for treatment of HBV
    Assembly Biosciences, Inc.
    03/19/23
  250. 145
    Amino acid compounds and methods of use
    Pliant Therapeutics, Inc.
    03/19/23
  251. 70
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    03/19/23
  252. 17
    Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
    Board of Regents, The University of Texas System
    03/19/23
  253. 158
    Cannabinoid receptor type 2 (CB2) modulators and uses thereof
    Teon Therapeutics, Inc.
    03/19/23
  254. 50
    Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists
    Trustees of Tufts College
    03/19/23
  255. 487
    Compounds and uses thereof
    Foghorn Therapeutics Inc.
    03/19/23
  256. 4
    Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex
    AlternOx Scientific Limited
    03/19/23
  257. 62
    Fused amino pyridine as HSP90 inhibitors
    Guris, Inc.
    03/19/23
  258. 377
    Indole compounds and analogues thereof
    BioCryst Pharmaceuticals, Inc.
    03/19/23
  259. 373
    Isoquinolines as inhibitors of HPK1
    Genentech, Inc.
    03/19/23
  260. 17
    Morpholinylpyridone compounds
    Sprint Bioscience AB
    03/19/23
  261. 175
    Proteasome activity enhancing compounds
    Proteostasis Therapeutics, Inc.
    03/19/23
  262. 22
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    03/19/23
  263. 718
    Ras inhibitors
    Revolution Medicines, Inc.
    03/19/23
  264. 149
    Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors
    Pfizer Inc.
    03/19/23
  265. 17
    2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    03/12/23
  266. 474
    ACLY inhibitors and uses thereof
    Nimbus Artemis, Inc.
    03/12/23
  267. 98
    Amide compounds as kinase inhibitors, compositions and methods of treatment
    Translational Drug Development LLC
    03/12/23
  268. 215
    Bruton's tyrosine kinase inhibitors
    SUZHOU BAIJIBUGONG PHARMACEUTICAL TECHNOLOGY CO., LTD.
    03/12/23
  269. 656
    PD-1/PD-L1 inhibitors
    Gilead Sciences, Inc.
    03/12/23
  270. 22
    Phosphonate linkers and their use to facilitate cellular retention of compounds
    Merck Sharp & Dohme LLC
    03/12/23
  271. 59
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    THE USA, AS REPRESENTED BY THE SECRETARY, DHHS
    03/12/23
  272. 46
    Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
    Amgen Inc.
    03/06/23
  273. 21
    Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
    Jazz Pharmaceuticals Ireland Limited
    03/06/23
  274. 109
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology Limited
    03/06/23
  275. 137
    Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof
    BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    03/06/23
  276. 23
    Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
    Gilead Sciences, Inc.
    03/06/23
  277. 581
    Transglutaminase 2 (TG2) inhibitors
    Sitari Pharma, Inc.
    03/06/23
  278. 80
    Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
    LegoChem Biosciences, Inc.
    03/05/23
  279. 822
    HPK1 antagonists and uses thereof
    Nimbus Saturn, Inc.
    03/05/23
  280. 523
    Heterocyclic compounds and uses thereof
    MILLENNIUM PHARMACEUTICALS, INC.
    03/05/23
  281. 238
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    BioSplice Therapeutics, Inc.
    03/05/23
  282. 45
    Kinase inhibitor compounds and compositions and methods of use
    ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    03/05/23
  283. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals, Inc.
    03/05/23
  284. 59
    Neprilysin inhibitors
    THERAVANCE BIOPHARMA R&D IP, LLC
    03/05/23
  285. 13
    Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1
    MANGOSUTHU UNIVERSITY OF TECHNOLOGY
    03/05/23
  286. 31
    Therapeutic compounds and methods of use thereof
    LIGATURE THERAPEUTICS PTE. LTD.
    03/05/23
  287. 5
    Amide compound having bet proteolysis-inducing action and medicinal application thereof
    MITSUBISHI TANABE PHARMA CORPORATION
    02/26/23
  288. 47
    BTK inhibitor compounds
    Eli Lilly and Company
    02/26/23
  289. 10
    Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer
    Janssen Pharmaceutica NV
    02/26/23
  290. 230
    Compositions and methods for treating CNS disorders
    Sage Therapeutics, Inc.
    02/26/23
  291. 6
    Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases
    SARBONNE UNIVERSITE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE; ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS; INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE; UNIVERSITÉ DE MONTPELLIER; ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
    02/26/23
  292. 65
    Compounds for the treatment of kinase-dependent disorders
    Exelixis, Inc.
    02/26/23
  293. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
    SHY Therapeutics LLC
    02/26/23
  294. 108
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    02/26/23
  295. 6
    IRAK degraders and uses thereof
    DANA-FARBER CANCER INSTITUTE, INC.
    02/26/23
  296. 27
    Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors
    UNIVERSISITY OF UTAH RESEARCH FOUNDATION
    02/26/23
  297. 42
    Phenothiazine derivatives and uses thereof
    CAMP4 THERAPEUTICS CORPORATION
    02/26/23
  298. 126
    Pyrazolopyrimidine compounds and uses thereof
    Incyte Corporation
    02/26/23
  299. 5
    Quinoline compounds as IRAK inhibitors and uses thereof
    Merck Patent GmbH
    02/26/23
  300. 17
    STK19 inhibitors for treatment of cancer
    TRUSTEES OF BOSTON UNIVERSITY; XIAMEN UNIVERSITY
    02/26/23
  301. 46
    Sting modulator compounds, and methods of making and using
    Takeda Pharmaceutical Company Limited
    02/26/23
  302. 51
    Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
    CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
    02/26/23
  303. 96
    Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
    AURIGENE DISCOVERY TECHNOLOGIES LIMITED
    02/26/23
  304. 71
    Substituted piperazines as selective HDAC1,2 inhibitors
    REGENACY PHARMACEUTICALS, LLC
    02/26/23
  305. 1
    Substituted piperidines as BTK inhibitors
    HAISCO PHARMACEUTICALS PTE. LTD.
    02/26/23
  306. 8
    Synthesis of peptide borate ester compound and use thereof
    JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO., LTD.
    02/26/23
  307. 5
    Tetrahydroisoquinoline derivatives, preparation process and use thereof
    Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
    02/26/23
  308. 94
    Therapeutic compounds and methods of use thereof
    Agency for Science, Technology and Research (A*STAR)
    02/26/23
  309. 16
    Analogs of dextromethorphan with balanced receptor activities
    Center for Neurologic Study
    02/20/23
  310. 11
    Benzisoxazole derivative
    Sumitomo Pharma Co., Ltd.
    02/20/23
  311. 155
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals, LLC
    02/20/23
  312. 15
    Dioxoloisoquinolinone derivatives and use thereof
    HANMI PHARMACEUTICAL CO., LTD.
    02/20/23
  313. 287
    Heterobicyclic amides as inhibitors of CD38
    Ribon Therapeutics, Inc.
    02/20/23
  314. 21
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    02/20/23
  315. 26
    Histone deacetylases (HDACs) inhibitors
    AnnJi Pharmaceutical Co., Ltd.
    02/20/23
  316. 115
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC
    02/20/23
  317. 100
    Isoindolines as HDAC inhibitors
    Valo Health, Inc.
    02/20/23
  318. 198
    MAP4K1 inhibitors
    Blueprint Medicines Corporation
    02/20/23
  319. 39
    Methods for treating depressive symptoms
    ALKERMES PHARMA IRELAND LIMITED
    02/20/23
  320. 85
    Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
    H. Lundbeck A/S
    02/20/23
  321. 10
    Pyrrolo[1,2-b] pyridazine derivatives
    Gilead Sciences, Inc.
    02/20/23
  322. 75
    Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof
    INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
    02/20/23
  323. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    02/17/23
  324. 228
    Compositions and methods for treating CNS disorders
    Sage Therapeutics, Inc.
    02/17/23
  325. 59
    Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
    NURIX THERAPEUTICS, INC.
    02/17/23
  326. 382
    Cyclic polypeptides for PCSK9 inhibition
    Merck Sharp & Dohme LLC; Ra Pharmaceuticals, Inc.
    02/17/23
  327. 3
    Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
    GENZYME CORPORATION
    02/17/23
  328. 17
    Ligands to cereblon (CRBN)
    DANA-FARBER CANCER INSTITUTE, INC.
    02/17/23
  329. 93
    Naphthyridinone derivatives and their use in the treatment of arrhythmia
    Novartis AG
    02/17/23
  330. 16
    Small molecule inhibition of transcription factor SALL4 and uses thereof
    DANA-FARBER CANCER INSTITUTE, INC.; THE BRIGHAM AND WOMEN''S HOSPITAL, INC.
    02/17/23
  331. 291
    Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    02/17/23
  332. 9
    Use of known compounds as D-amino acid oxidase inhibitors
    National Taiwan University; National Yang Ming Chiao Tung University; National Health Research Institutes
    02/17/23
  333. 431
    2-(morpholin-4-yl)-1,7-naphthyridines
    Bayer Pharma Aktiengesellschaft
    02/16/23
  334. 30
    Alpha-5 beta-1 inhibitors
    The Regents of the University of California; Shanghai ChemPartner Co., Ltd.
    02/16/23
  335. 45
    Analogs for the treatment of disease
    Insilico Medicine IP Limited
    02/16/23
  336. 45
    Analogs for the treatment of disease
    Insilico Medicine IP Limited
    02/16/23
  337. 63
    Compositions and methods for treating infections
    Vyera Pharmaceuticals, LLC
    02/16/23
  338. 31
    Compounds
    INFLAZOME LIMITED
    02/16/23
  339. 9
    Imidazo[4,5-C]pyridine derived SSAO inhibitors
    PROXIMAGEN, LLC
    02/16/23
  340. 123
    Kinase inhibitors
    The University of Manchester
    02/16/23
  341. 31
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb Company
    02/16/23
  342. 17
    Protacs targeting coronavirus 3CL protease and preparation method and application thereof
    SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
    02/16/23
  343. 51
    SHP2 phosphatase inhibitors and methods of use thereof
    Relay Therapeutics, Inc.; D. E. Shaw Research, LLC
    02/16/23
  344. 61
    Use of aminomethylenecyclohexane-1,3-dione compound
    WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    02/16/23
  345. 717
    Heterocyclic compound as a protein kinase inhibitor
    HK inno.N Corporation
    02/13/23
  346. 14
    JAK kinase inhibitor and preparation method and use thereof
    SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD.
    02/13/23
  347. 31
    Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)
    Prelude Therapeutics, Incorporated
    02/13/23
  348. 7
    Alkyne substituted quinazoline compound and methods of use
    Newgen Therapeutics, Inc.
    02/12/23
  349. 10
    Compounds for treating ILK-mediated diseases
    The Cleveland Clinic Foundation
    02/12/23
  350. 1076
    Indole and azaindole inhibitors of pad enzymes
    Bristol-Myers Squibb Company
    02/12/23
  351. 310
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences, Inc.
    02/12/23
  352. 7
    Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine
    VTV THERAPEUTICS LLC
    02/12/23
  353. 15
    Pyrazole compounds as LSD1 inhibitors and applications thereof
    MEDSHINE DISCOVERY INC.
    02/12/23
  354. 58
    CDPK1 inhibitors, compositions, and methods related thereto
    Vyera Pharmaceuticals, LLC; Washington University
    02/05/23
  355. 11
    Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    Kronos Bio, Inc.
    02/05/23
  356. 50
    Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    NIKANG THERAPEUTICS, INC.
    02/05/23
  357. 8
    Inhibitors of DNMT1 as anticancer therapeutic agents
    Victoria Link Limited; Albert Einstein College of Medicine
    02/05/23
  358. 15
    MTOR inhibitor compounds
    GALDERMA RESEARCH & DEVELOPMENT
    02/05/23
  359. 2
    Macrocycle and composition comprising thereof
    Shenzhen TargetRx, Inc.
    02/05/23
  360. 9
    Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof
    SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
    02/05/23
  361. 10
    Radiolabeled pharmaceuticals and methods of making and using same
    YALE UNIVERSITY
    02/05/23
  362. 370
    Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction
    ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
    02/05/23
  363. 59
    Compounds useful in HIV therapy
    GlaxoSmithKline Intellectual Property Development Limited; The University of North Carolina at Chapel Hill; ViiV Healthcare Company
    01/31/23
  364. 50
    Aminocyclobutanes as monoacylglycerol lipase modulators
    Janssen Pharmaceutica NV
    01/28/23
  365. 250
    Anti-tumor effect potentiator using novel biphenyl compound
    Taiho Pharmaceutical Co., Ltd.
    01/28/23
  366. 16
    BRK inhibitory compound
    ONO PHARMACEUTICAL CO., LTD.
    01/28/23
  367. 102
    CRBN ligands and uses thereof
    KYMERA THERAPEUTICS, INC.
    01/28/23
  368. 139
    Compounds and methods for the enhanced degradation of targeted proteins
    Arvinas Operations, Inc.; Yale University
    01/28/23
  369. 1
    Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof
    Shenzhen TargetRx, Inc.
    01/28/23
  370. 107
    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
    Takeda Pharmaceutical Company Limited
    01/28/23
  371. 35
    2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy
    THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING
    01/21/23
  372. 3
    Aryl-piperidine derivatives
    Artax Biopharma Inc.
    01/21/23
  373. 76
    Azaspirocycles as monoacylglycerol lipase modulators
    Janssen Pharmaceutica NV
    01/21/23
  374. 159
    Compounds and methods for treating oxalate-related diseases
    OxaluRx, Inc.
    01/21/23
  375. 138
    Dihydroorotate dehydrogenase inhibitors
    TBA
    01/21/23
  376. 19
    HDAC8 inhibitors for treating cancer
    CITY OF HOPE; TAIPEI MEDICAL UNIVERSITY; ACADEMIA SINICA
    01/21/23
  377. 62
    Inhibitors of fibroblast activation protein
    PRAXIS BIOTECH LLC
    01/21/23
  378. 81
    SSAO inhibitor
    TBA
    01/21/23
  379. 3
    Tetrahydroquinoline derivatives and a process of preparation thereof
    KING ABDULAZIZ UNIVERSITY
    01/21/23
  380. 30
    Therapeutic compounds and methods of use thereof
    LIGATURE THERAPEUTICS PTE. LTD.
    01/21/23
  381. 196
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    01/20/23
  382. 150
    ACLY inhibitors and uses thereof
    Nimbus Artemis, Inc.
    01/20/23
  383. 45
    Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
    Janssen Sciences Ireland Unlimited Company
    01/20/23
  384. 120
    Benzisoxazole sulfonamide derivatives
    Pfizer Inc.; CTXT PTY LTD
    01/20/23
  385. 23
    Cyclic dinucleotides as sting agonists
    Janssen Biotech, Inc.
    01/20/23
  386. 24
    Cyclic peptide immunomodulators
    Bristol-Myers Squibb Company
    01/20/23
  387. 54
    Indazole compounds and uses thereof
    Incyte Corporation
    01/20/23
  388. 320
    MTA-cooperative PRMT5 inhibitors
    Mirati Therapeutics, Inc.
    01/20/23
  389. 66
    N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
    Nerviano Medical Sciences S.R.L.
    01/20/23
  390. 7
    Peptides for treatment of medical disorders
    Humanwell Pharmaceutical US
    01/20/23
  391. 4
    Therapeutic methods and combinations
    TBA
    01/20/23
  392. 2
    Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase
    Hanmi Pharm. Co., Ltd.
    01/20/23
  393. 153
    Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
    Neuropore Therapies, Inc.
    01/20/23
  394. 26
    Azaindolylpyridone and diazaindolylpyridone compounds
    Sprint Bioscience AB
    01/17/23
  395. 38
    Dopamine D2 receptor ligands
    The Broad Institute, Inc.; Massachusetts Institute of Technology
    01/17/23
  396. 152
    Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
    BLUERAY THERAPEUTICS (SHANGHAI) CO., LTD
    01/17/23
  397. 275
    Tricyclic heterocycles as BET protein inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    01/17/23
  398. 368
    Amido spirocyclic amide and sulfonamide derivatives
    Valo Health, Inc.; Genentech, Inc.
    01/06/23
  399. 137
    Compounds and methods useful in the treatment of a PRMT5-mediated disorder
    ARGONAUT THERAPEUTICS LIMITED
    01/06/23
  400. 140
    Compounds for inhibiting TNIK and medical uses thereof
    KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    01/06/23
  401. 127
    Compounds for treatment of PD-L1 diseases
    ChemoCentryx, Inc.
    01/06/23
  402. 2
    Deuterated compounds as rock inhibitors
    Fochon Pharmaceuticals, Ltd.
    01/06/23
  403. 82
    Mu opioid receptor modulators
    The Regents of the University of California; Friedrich-Alexander-Universität Erlangen-Nürnberg; The Board of Trustees of the Leland Stanford Junior University; The University of North Carolina at Chapel Hill
    01/06/23
  404. 35
    N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
    Boehringer Ingelheim International GmbH
    01/06/23
  405. 222
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    MIRATI THERAPEUTICS, INC.
    01/06/23
  406. 121
    Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors
    KSQ Therapeutics, Inc.
    01/06/23
  407. 5
    Synthesis of (+)-cannabinoids and their therapeutic effects
    SYMRISE AG
    01/06/23
  408. 222
    2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
    HUTCHISON MEDIPHARMA LIMITED
    12/30/22
  409. 66
    5-5 fused rings as C5a inhibitors
    CHEMOCENTRYX, INC.
    12/30/22
  410. 6
    5-aminolevulinate synthase inhibitors and methods of use thereof
    University of South Florida
    12/30/22
  411. 486
    Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
    CHEMOCENTRYX, INC.
    12/30/22
  412. 38
    EP4 antagonist
    ONO PHARMACEUTICAL CO., LTD.
    12/30/22
  413. 49
    Heterocyclic RIP1 kinase inhibitors
    Rigel Pharmaceuticals, Inc.
    12/30/22
  414. 71
    Inhibitors of Rho associated coiled-coil containing protein kinase
    Kadmon Corporation, LLC
    12/30/22
  415. 321
    MTA-cooperative PRMT5 inhibitors
    Mirati Therapeutics, Inc.
    12/30/22
  416. 70
    Macrocyclic chlorine substituted indole derivatives
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.
    12/30/22
  417. 6
    Method for treating inflammation
    KING FAISAL UNIVERSITY
    12/30/22
  418. 225
    OX2R compounds
    TBA
    12/30/22
  419. 14
    Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
    The Johns Hopkins University
    12/30/22
  420. 154
    Small molecule modulators of the BTB domain of Keap1
    MedImmune Limited
    12/30/22
  421. 4
    Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
    Newave Pharmaceutical Inc.
    12/30/22
  422. 4
    Substituted piperidine compounds and their use
    Eisai R&D Management Co., Ltd.
    12/30/22
  423. 5
    Targeted drug rescue with novel compositions, combinations, and methods thereof
    TBA
    12/30/22
  424. 24
    Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
    Bristol-Myers Squibb Company
    12/30/22
  425. 94
    Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof
    BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    12/30/22
  426. 35
    1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof
    SOUTHERN MEDICAL UNIVERSITY
    12/24/22
  427. 27
    1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
    AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO—A.C.R.A.F. S.p.A.
    12/24/22
  428. 52
    Acyclic antivirals
    JANSSEN PHARMACEUTICA NV
    12/24/22
  429. 14
    Cyclic dinucleotides as sting agonists
    Janssen Biotech, Inc.
    12/24/22
  430. 111
    Imidazopyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    12/24/22
  431. 67
    Inhibitors of blood coagulation factor XIII
    Zedira GmbH
    12/24/22
  432. 172
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences, Inc.
    12/24/22
  433. 1
    Mcl-1 inhibitors and methods of use thereof
    AstraZeneca AB
    12/24/22
  434. 37
    Pyrazolo[1,5-a]pyrazin-4-yl derivatives
    Pfizer Inc.
    12/24/22
  435. 186
    Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist
    BEIGENE, LTD.
    12/24/22
  436. 79
    Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
    Array BioPharma Inc.
    12/24/22
  437. 95
    Tricyclic compounds and their use as phosphodiesterase inhibitors
    PFIZER, INC.
    12/24/22
  438. 35
    Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases
    BEIGENE, LTD.
    12/23/22
  439. 11
    Compounds for treatment of hypoproliferative disorders
    LU LICENSE AB
    12/23/22
  440. 27
    Diacylglycerol acyl transferase 2 inhibitor
    Pfizer Inc.
    12/23/22
  441. 5
    Docosahexaenoic acid endocannabinoid epoxide derivative compositions
    The Board of Trustees of the University of Illinois
    12/23/22
  442. 279
    Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
    Incyte Corporation
    12/23/22
  443. 18
    Quinazolinones that inhibit the formation of tau oligomers and their method of use
    Oligomerix, Inc.
    12/23/22
  444. 93
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    12/23/22
  445. 146
    SSAO inhibitors and use thereof
    Eccogene (Shanghai) Co., Ltd.
    12/23/22
  446. 19
    Sphingosine analogs and use thereof against bacterial lung infections
    Yeda Research and Development Co. Ltd.; University of Duisburg-Essen
    12/23/22
  447. 51
    3-substituted piperidine compounds for Cbl-b inhibition, and use thereof
    Nurix Therapeutics, Inc.
    12/11/22
  448. 69
    Compound functioning as bromodomain protein inhibitor, and composition
    Betta Pharmaceuticals Co., Ltd.
    12/11/22
  449. 48
    Compound having ERK kinase inhibitory activity and use thereof
    SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    12/11/22
  450. 10
    Cyclic di-nucleotide compounds as sting agonists
    Merck Sharp & Dohme LLC
    12/11/22
  451. 13
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    12/11/22
  452. 94
    Heterocyclic inhibitors of PTPN11
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    12/11/22
  453. 16
    Modulators of the NMDA receptor
    H. Lundbeck A/S
    12/11/22
  454. 60
    Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
    SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
    12/11/22
  455. 142
    Pharmaceutical compounds
    OTSUKA PHARMACEUTICAL CO., LTD.; TAIHO PHARMACEUTICAL CO., LTD.
    12/11/22
  456. 31
    Pyridazines
    Boehringer Ingelheim International GmbH
    12/11/22
  457. 187
    Substituted lactams showing serotonin 5-HT receptor activity
    SUMITOMO PHARMA CO., LTD.
    12/11/22
  458. 21
    Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
    Enanta Pharmaceuticals, Inc.
    12/11/22
  459. 27
    Tricyclic compounds
    JACOBIO PHARMACEUTICALS CO., LTD.
    12/11/22
  460. 15
    2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same
    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VANDERBILT UNIVERSITY
    12/07/22
  461. 286
    6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors
    Novartis AG
    12/07/22
  462. 20
    Annulated glycosidase inhibitors
    Asceneuron SA
    12/07/22
  463. 30
    Antibacterial compounds
    INFEX Therapeutics Limited
    12/07/22
  464. 140
    Biaryl derivative, preparation method thereof and pharmaceutical application thereof
    ABBISKO THERAPEUTICS CO., LTD.
    12/07/22
  465. 72
    Broad spectrum antiviral compositions and methods
    Evrys Bio, LLC
    12/07/22
  466. 74
    Broad spectrum inhibitors of filoviruses
    Microbiotix, Inc.; Albert Einstein College of Medicine; The Government of the United States as Represented by the Secretary of the Army
    12/07/22
  467. 3
    Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors
    Suven Life Sciences Limited
    12/07/22
  468. 3
    Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
    PHARMAKEA, INC.
    12/07/22
  469. 108
    Heterocyclic compounds for the inhibition of PASK
    BioEnergenix LLC
    12/07/22
  470. 71
    Imidazopyridazine and imidazopyridine compounds and uses thereof
    Incyte Corporation
    12/07/22
  471. 48
    Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor
    Chia Tai Tianqing Pharmaceutical Group Co., Inc.
    12/07/22
  472. 227
    Modulators of methyl modifying enzymes, compositions and uses thereof
    Constellation Pharmaceuticals, Inc.
    12/07/22
  473. 160
    N/O-linked Degrons and Degronimers for protein degradation
    C4 Therapeutics, Inc.
    12/07/22
  474. 67
    Pyrazine carbamates and their use as GluN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    12/07/22
  475. 5
    Substituted pyrrolo[2,3-d]pyrimidines as JAK inhibitors
    VIMALAN BIOSCIENCES, INC.
    12/07/22
  476. 229
    TEAD inhibitors and uses thereof
    IKENA ONCOLOGY, INC.
    12/07/22
  477. 36
    Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
    NIKANG THERAPEUTICS, INC.
    12/07/22
  478. 15
    3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    MINDSET PHARMA INC.
    12/04/22
  479. 215
    Cyclic di-nucleotide compounds as sting agonists
    Merck Sharp & Dohme LLC
    12/04/22
  480. 25
    JAK inhibitors containing a 4-membered heterocyclic amide
    THERAVANCE BIOPHARMA R&D IP, LLC
    12/04/22
  481. 452
    KRas G12D inhibitors
    MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA INC.
    12/04/22
  482. 143
    Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
    BEIJING TIDE PHARMACEUTICAL CO., LTD.
    12/04/22
  483. 576
    Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    12/04/22
  484. 16
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
    ELI LILLY AND COMPANY
    12/04/22
  485. 72
    Substituted eneoxindoles and uses thereof
    Gilead Sciences, Inc.
    12/04/22
  486. 44
    Substituted propanamides as inhibitors of nucleases
    MASARYKOVA UNIVERZITA
    12/04/22
  487. 1
    Substituted pyrazolo[1,5-a]pyrimidines as tropomyosin receptor kinase inhibitors
    SHENZHEN TARGETRX, INC.
    12/04/22
  488. 29
    Tricyclic compounds useful to treat orthomyxovirus infections
    Novartis AG
    12/04/22
  489. 4
    (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
    Histogen, Inc.
    11/20/22
  490. 66
    Galactoside inhibitor of galectins
    GALECTO BIOTECH AB
    11/20/22
  491. 49
    Macrocyclic chlorine substituted indole derivatives
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.
    11/20/22
  492. 225
    Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer
    Cancer Research Technology Limited
    11/20/22
  493. 12
    Tricyclic amine compounds as CDK2 inhibitors
    Incyte Corporation
    11/20/22
  494. 360
    Aminoimidazopyridazines as kinase inhibitors
    Bristol-Myers Squibb Company
    11/19/22
  495. 116
    Anti-inflammatory compound, and preparation and use thereof
    E-Nitiate Biopharmaceuticals (Hangzhou) Co., Ltd.
    11/19/22
  496. 25
    Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof
    SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
    11/19/22
  497. 83
    Compound exhibiting enteropeptidase inhibitory activity
    LG CHEM, LTD.
    11/19/22
  498. 90
    Compounds, salts thereof and methods for treatment of diseases
    ACADIA PHARMACEUTICALS INC.
    11/19/22
  499. 64
    Cyclic compound having dopamine D3 receptor antagonistic effect
    SHIONOGI & CO., LTD.
    11/19/22
  500. 10
    Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof
    Korea Research Institute of Chemical Technology; Industry-Academic Cooperation Foundation, Yonsei University
    11/19/22
  501. 32
    Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors
    Recordati Industria Chimica e Farmacentica S.p.A.
    11/19/22
  502. 33
    Indoleamine-2,3-dioxygenase inhibitor, the preparative method and the use thereof
    HINOVA PHARMACEUTICALS INC.
    11/19/22
  503. 95
    Inhibitors of cyclin-dependent kinases
    TBA
    11/19/22
  504. 118
    Pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    11/19/22
  505. 46
    Pyrimidine JAK inhibitors for the treatment of skin diseases
    THERAVANCE BIOPHARMA R&D IP, LLC
    11/19/22
  506. 98
    Pyrimidine TBK/IKKe inhibitor compounds and uses thereof
    Merck Patent GmbH
    11/19/22
  507. 7
    Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
    NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD.
    11/19/22
  508. 5
    Selective A2A receptor antagonist
    INXMED (NANJING) CO., LTD.
    11/19/22
  509. 94
    Spiroheptanyl hydantoins as rock inhibitors
    Bristol-Myers Squibb Company
    11/19/22
  510. 6
    Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity
    The Board of Trustees of the Leland Stanford Junior University
    11/19/22
  511. 79
    Substituted macrocyclic indole derivatives
    TBA
    11/19/22
  512. 30
    Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
    TBA
    11/19/22
  513. 353
    Tetrahydroquinoline derivatives as P2X7 receptor antagonists
    RaQualia Pharma Inc.; Asahi Kasei Pharma Corporation
    11/19/22
  514. 22
    Triazolo-azepine derivatives
    Hoffmann-La Roche Inc.
    11/19/22
  515. 32
    Tricyclic amine compounds as CDK2 inhibitors
    Incyte Corporation
    11/19/22
  516. 10
    p38α mitogen-activated protein kinase inhibitors
    GEN1E LIFESCIENCES INC.
    11/19/22
  517. 12
    ASK1 inhibitor compounds and uses thereof
    SEAL ROCK THERAPEUTICS, INC.
    11/13/22
  518. 56
    ATR inhibitor and application thereof
    Wuxi Biocity Biopharmaceutics Co., Ltd.
    11/13/22
  519. 129
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    11/13/22
  520. 359
    Heterocyclylamines as PI3K inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    11/13/22
  521. 164
    LSD1 inhibitor and preparation method and application thereof
    MEDSHINE DISCOVERY INC.
    11/13/22
  522. 70
    PDE9 inhibitor and use thereof
    Nanjing TransThera Biosciences Co. Ltd.
    11/13/22
  523. 17
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech, Inc.
    11/13/22
  524. 166
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    11/13/22
  525. 70
    Aryl cyclopropyl-amino-isoquinolinyl amide compounds
    Aerie Pharmaceuticals, Inc.
    11/07/22
  526. 69
    Bromodomain inhibitor compound and use thereof
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Suzhou Suplead Life Sciences Co., Ltd.
    11/07/22
  527. 124
    Composition and methods for inhibiting mammalian sterile 20-like kinase 1
    THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITÄT BREMEN
    11/07/22
  528. 8
    Cycloalkyl-diamines for the treatment of inflammation
    MediSynergics, LLC
    11/07/22
  529. 291
    Dihydrooxadiazinones
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.
    11/07/22
  530. 40
    IRAK4 inhibiting agents
    BIOGEN MA INC.
    11/07/22
  531. 84
    Imidazo-pyridine compounds as PAD inhibitors
    JUBILANT EPIPAD LLC
    11/07/22
  532. 465
    Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
    Incyte Corporation
    11/07/22
  533. 312
    Immunomodulator compounds
    ChemoCentryx, Inc.
    11/07/22
  534. 332
    Indazoles and azaindazoles as LRRK2 inhibitors
    ESCAPE Bio, Inc.
    11/07/22
  535. 543
    Inhibitors of KEAP1-Nrf2 protein-protein interaction
    Janssen Pharmaceutica NV
    11/07/22
  536. 22
    JAK inhibitor and use thereof
    ZHUHAI UNITED LABORATORIES CO., LTD.
    11/07/22
  537. 13
    Kinase inhibitors
    Insilico Medicine IP Limited
    11/07/22
  538. 24
    Prolyl hydroxylase inhibitors and methods of use
    Akebia Therapeutics, Inc.
    11/07/22
  539. 4
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma Inc.
    11/07/22
  540. 84
    Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
    The Johns Hopkins University; Institute of Organic Chemistry & Biochemistry
    11/07/22
  541. 228
    Substituted pyrrolopyridine-derivatives
    Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft; Deutsches Krebsforschungszentrum
    11/07/22
  542. 1
    Substituted quinolines useful as kinase inhibitors
    Teligene Ltd.
    11/07/22
  543. 22
    4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
    NERVIANO MEDICAL SCIENCES S.R.L.
    11/06/22
  544. 208
    Amide substituted indole compounds useful as TLR inhibitors
    Bristol-Myers Squibb Company
    11/06/22
  545. 29
    Arginase inhibitors and methods of use thereof
    AstraZeneca AB
    11/06/22
  546. 452
    Aryl and heteroaryl substituted indole compounds
    Bristol-Myers Squibb Company
    11/06/22
  547. 589
    Bcl-2 inhibitors
    BEIGENE, LTD.
    11/06/22
  548. 150
    Bicyclic compounds
    VIVACE THERAPEUTICS, INC.
    11/06/22
  549. 18
    Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    XWPHARMA LTD.
    11/06/22
  550. 26
    DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof
    Yunnan University; Kunming Institute of Zoology, Chinese Academy of Sciences
    11/06/22
  551. 145
    Dosage forms and regimens for amino acid compounds
    Pliant Therapeutics, Inc.
    11/06/22
  552. 67
    Heterocyclic compounds as anti-viral agents
    ENANTA PHARMACEUTICALS, INC.
    11/06/22
  553. 16
    Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
    NIKANG THERAPEUTICS, INC.
    11/06/22
  554. 316
    Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents
    NOVARTIS AG
    11/06/22
  555. 39
    Substituted imidazo[1,5-a]pyrazines as Bruton's tyrosine kinase inhibitors
    TRANSTHERA SCIENCES (NANJING), INC.
    11/06/22
  556. 67
    Substituted pyrrolopyridines as JAK inhibitors
    TBA
    11/06/22
  557. 30
    Treatment of tachycardia
    OSLO UNIVERSITY HOSPITAL HF
    11/06/22
  558. 53
    AMPK activators
    KALLYOPE, INC.
    11/05/22
  559. 22
    Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
    Gwangju Institute of Science and Technolgy; Korea Advanced Institute of Science and Technology; KyungPook National University Industry-Academic Cooperation Foundation; Curacle Co., LTD.
    11/05/22
  560. 149
    Compounds and uses thereof
    Foghorn Therapeutics Inc.
    10/30/22
  561. 78
    Compounds for the treatment of BRAF-associated diseases and disorders
    Array BioPharma Inc.
    10/30/22
  562. 5
    Compounds useful as immunomodulators
    Bristol-Myers Squibb Company
    10/30/22
  563. 97
    Formulations of Tie-2 activators and methods of use thereof
    EYEPOINT PHARMACEUTICALS, INC.
    10/30/22
  564. 55
    Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
    Suzhou Longbiotech Pharmaceuticals Co., Ltd.
    10/30/22
  565. 66
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    10/30/22
  566. 136
    Heterocyclic compounds as modulators of mGluR7
    Pragma Therapeutics
    10/30/22
  567. 212
    Inhibitors of protein kinases
    Alexion Pharmaceuticals, Inc.
    10/30/22
  568. 19
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland UniServices Limited
    10/30/22
  569. 103
    Oxoacridinyl acetic acid derivatives and methods of use
    STINGTHERA, INC.
    10/30/22
  570. 379
    P300/CBP hat inhibitors
    Constellation Pharmaceuticals, Inc.
    10/30/22
  571. 1022
    Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
    Nimbus Lakshmi, Inc.
    10/30/22
  572. 37
    Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors
    MISSION THERAPEUTICS LIMITED
    10/30/22
  573. 6
    Acetamide thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute, Inc.
    10/28/22
  574. 58
    Antibacterial compounds
    FORGE THERAPEUTICS, INC.
    10/28/22
  575. 121
    Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    10/28/22
  576. 80
    CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
    AMGEN INC.
    10/28/22
  577. 3
    Derivatives of an FGFR inhibitor
    Incyte Corporation
    10/28/22
  578. 36
    Dioxinoquinoline compounds, preparation method and uses thereof
    BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    10/28/22
  579. 114
    Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
    Development Center for Biotechnology
    10/28/22
  580. 27
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    10/28/22
  581. 85
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    10/28/22
  582. 26
    JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
    Incyte Corporation
    10/28/22
  583. 118
    Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
    Washington University
    10/28/22
  584. 16
    Pyrazolopyridine compounds and uses thereof
    Incyte Corporation
    10/28/22
  585. 208
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    10/28/22
  586. 13
    Substituted piperidines as kinase inhibitors
    Daewoong Pharmaceutical Co., Ltd.
    10/28/22
  587. 13
    Treatment of upper aerodigestive tract disorders and cough
    TBA
    10/28/22
  588. 79
    Tropomyosin-related kinase (TRK) inhibitors
    Genzyme Corporation
    10/28/22
  589. 22
    1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    NOVARTIS AG
    10/23/22
  590. 153
    Alcoxyamino derivatives for treating pain and pain related conditions
    ESTEVE PHARMACEUTICALS, S.A.
    10/23/22
  591. 1
    Biochemical binding of RET9 and VEGFR2 inhibitors
    Kala Pharmaceuticals, Inc.
    10/23/22
  592. 23
    Cyclic dinucleotide compound and uses thereof
    SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD.; JIANGXI JEMINCARE GROUP CO., LTD.
    10/23/22
  593. 64
    Dihydroquinolinones for medical treatment
    C4 Therapeutics, Inc.
    10/23/22
  594. 307
    Heteroaryl inhibitors of PDE4
    Tetra Discovery Partners, LLC
    10/23/22
  595. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte Corporation
    10/23/22
  596. 11
    Isoquinoline derivatives and use thereof
    Purdue Pharma L.P.
    10/23/22
  597. 62
    Macrocyclic indole derivatives
    The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    10/23/22
  598. 40
    Pyrido[3,2-d]pyrimidine compounds as immunomodulators
    Incyte Corporation
    10/23/22
  599. 81
    Pyrimidinones as PI3K inhibitors
    Incyte Holdings Corporation; Incyte Corportion
    10/23/22
  600. 41
    Small molecule activators of Parkin enzyme function
    Mayo Foundation for Medical Education and Research
    10/23/22
  601. 8
    [1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
    ELI LILLY AND COMPANY
    10/23/22
  602. 23
    1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
    THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    10/17/22
  603. 34
    Amine compound for inhibiting SSAO/VAP-1 and use thereof
    SUNSHINE LAKE PHARMA CO., LTD.
    10/17/22
  604. 15
    Amino acid compounds with unbranched linkers and methods of use
    Pliant Therapeutics, Inc.
    10/17/22
  605. 21
    Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    10/17/22
  606. 479
    Benzodiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals, Inc.
    10/17/22
  607. 218
    CDK2/4/6 inhibitors
    Pfizer Inc.
    10/17/22
  608. 45
    Substituted heterocyclic derivatives as PI3K inhibitors
    Incyte Corporation
    10/17/22
  609. 601
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    10/17/22
  610. 2
    Tricyclic compounds as Cyp1 inhibitors
    The General Hospital Corporation
    10/17/22
  611. 267
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics Limited
    10/16/22
  612. 66
    Arginase inhibitors as therapeutics
    Mars, Incorporated
    10/16/22
  613. 104
    Compounds and methods for treating oxalate-related diseases
    OxaluRx, Inc.
    10/16/22
  614. 34
    Compounds for targeting mutant huntingtin protein and uses thereof
    CHDI Foundation, Inc.
    10/16/22
  615. 159
    Inhibitors of cyclin-dependent kinases
    KINNATE BIOPHARMA INC.
    10/16/22
  616. 7
    Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof
    Beijing Innocare Pharma Tech Co., Ltd.
    10/16/22
  617. 215
    Piperazine derivatives as MAGL inhibitors
    Hoffmann-La Roche Inc.
    10/16/22
  618. 47
    Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors
    Incyte Corporation
    10/16/22
  619. 314
    Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
    BEIJING TIDE PHARMACEUTICAL CO., LTD.
    10/16/22
  620. 38
    Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application
    GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    10/09/22
  621. 1
    Diphenylaminopyrimidine compound for inhibiting kinase activity
    Shenzhen TargetRx, Inc.
    10/09/22
  622. 20
    Heterocyclic compound as CSF-1R inhibitor and use thereof
    MEDSHINE DISCOVERY INC.
    10/09/22
  623. 45
    Heterocyclic compounds useful as aurora a selective inhibitors
    Jacobio Pharmaceuticals Co., Ltd.
    10/09/22
  624. 120
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    10/09/22
  625. 7
    Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
    UNION therapeutics A/S
    10/09/22
  626. 19
    Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
    Incyte Corporation
    10/09/22
  627. 209
    2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
    Merck Sharp & Dohme LLC
    10/06/22
  628. 132
    CD73 inhibitors
    ORIC PHARMACEUTICALS, INC.
    10/06/22
  629. 106
    Galactoside inhibitor of galectins
    Galecto Biotech AB
    10/06/22
  630. 164
    Heterocyclic prolinamide derivatives
    ORION OPHTHALMOLOGY LLC
    10/06/22
  631. 41
    Acetyl-CoA carboxylase modulators
    Monsanto Technology LLC
    10/05/22
  632. 20
    Inhibiting mutant IDH-1
    FORMA Therapeutics, Inc.
    10/05/22
  633. 56
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    10/05/22
  634. 19
    Inhibitors of histone deacetylase
    The Broad Institute, Inc.; The General Hospital Corporation
    10/05/22
  635. 34
    Purine derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    10/05/22
  636. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    10/05/22
  637. 177
    Serine/threonine kinase inhibitors
    Genentech, Inc.
    10/05/22
  638. 32
    3-arylindazoles as selective MEK4 inhibitors
    NORTHWESTERN UNIVERSITY
    09/25/22
  639. 10
    Antimalarial compounds, process for preparation and their use for drug resistant malaria
    Council of Scientific and Industrial Research; International Centre for Genetic Engineering and Biotechnology (ICGEB)
    09/25/22
  640. 229
    Compounds
    TMEM16A LIMITED
    09/25/22
  641. 23
    Compounds and methods for inhibiting CPY26 enzymes
    Queen''s University at Kingston
    09/25/22
  642. 54
    Compounds that inhibit Mcl-1 protein
    AMGEN INC.
    09/25/22
  643. 549
    Compounds useful as inhibitors of ATR kinase
    VERTEX PHARMACEUTICALS INCORPORATED
    09/25/22
  644. 92
    Cyano-substituted heterocycles with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    09/25/22
  645. 79
    FGFR inhibitor and application thereof
    Betta Pharmaceuticals Co., Ltd.
    09/25/22
  646. 598
    GLS1 inhibitors for treating disease
    Board of Regents, The University of Texas System
    09/25/22
  647. 21
    Heteroaryl plasma kallikrein inhibitors
    Takeda Pharmaceutical Company Limited
    09/25/22
  648. 60
    Heterocyclic inhibitors of tyrosine kinase
    Board of Regents, The University of Texas System
    09/25/22
  649. 124
    Imidazolidin-2-one compounds as PRMT5 modulators
    AURIGENE DISCOVERY TECHNOLOGIES LIMITED
    09/25/22
  650. 27
    Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds
    Eli Lilly and Company
    09/25/22
  651. 365
    Melt-extruded solid dispersions containing an apoptosis-inducing agent
    AbbVie Inc.; AbbVie Deutschland GMBH & Co KG
    09/25/22
  652. 10
    Optically active azabicyclo ring derivative
    Sumitomo Dainippon Pharma Co., Ltd.
    09/25/22
  653. 17
    P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof
    SHANGHAI ZHIMENG BIOPHARMA INC.
    09/25/22
  654. 47
    Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer
    PELEMED CO., LTD.
    09/25/22
  655. 5
    Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
    Imara Inc.
    09/25/22
  656. 447
    Pyridine compound substituted with azole
    TAISHO PHARMACEUTICAL CO., LTD.
    09/25/22
  657. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals Inc.
    09/25/22
  658. 14
    Substituted benzimidazoles, their preparation and their use as pharmaceuticals
    EPIGENETIX, INC.
    09/25/22
  659. 528
    Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
    BioCryst Pharmaceuticals, Inc.
    09/25/22
  660. 185
    Substituted cyclohexyl compounds as NOP inhibiiors
    Dart NeuroScience, LLC
    09/25/22
  661. 73
    Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    Union therapeutics A/S
    09/25/22
  662. 62
    Substituted pyrazoles as LRRK2 inhibitors
    OSCOTEC INC.
    09/25/22
  663. 7
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    09/25/22
  664. 31
    CRBN ligands and uses thereof
    KYMERA THERAPEUTICS, INC.
    09/19/22
  665. 9
    Compounds and methods for inhibiting CYP26 enzymes
    Queen''s University at Kingston
    09/19/22
  666. 29
    Functionalized peptides as antiviral agents
    Enanta Pharmaceuticals, Inc.
    09/19/22
  667. 102
    Lysyl oxidase-like 2 inhibitors and uses thereof
    PharmAkea, Inc.
    09/19/22
  668. 12
    Prodrugs of modulators of the NMDA receptor
    H. Lundbeck A/S
    09/19/22
  669. 56
    Compounds useful as RET inhibitors
    Cancer Research Technology Limited
    09/11/22
  670. 122
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    09/11/22
  671. 305
    TGF-beta inhibitors
    Rigel Pharmaceuticals, hic.; Bristol-Myers Squibb Company
    09/11/22
  672. 198
    1-cyano-pyrrolidine derivatives as DUB inhibitors
    MISSION THERAPEUTICS LIMITED
    09/10/22
  673. 261
    2,4-disubstituted pyrimidines useful as kinase inhibitors
    Celgene CAR LLC
    09/10/22
  674. 163
    Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
    Jubilant Epicore LLC
    09/10/22
  675. 347
    HIV protease inhibitors
    Gilead Sciences, Inc.
    09/10/22
  676. 324
    Inhibitors of plasma kallikrein and uses thereof
    Takeda Pharmaceutical Company Limited
    09/10/22
  677. 89
    Nitrile-containing antiviral compounds
    Pfizer Inc.
    09/10/22
  678. 210
    Phenoxymethyl derivatives
    Hoffmann-La Roche Inc.
    09/10/22
  679. 281
    Pyridine and pyridimine compounds as PI3K-gamma inhibitors
    Incyte Corporation
    09/10/22
  680. 33
    Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
    Xiamen University
    09/10/22
  681. 16
    Substituted pyrimidines as CDK4/6 inhibitors
    Beijing Xuanyi PharmaSciences Co., Ltd.
    09/10/22
  682. 241
    2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
    TBA
    09/05/22
  683. 33
    Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds
    PHARMAKEA, INC.
    09/05/22
  684. 152
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    09/05/22
  685. 28
    Autotaxin inhibitor compounds
    Sabre Therapeutics LLC
    09/05/22
  686. 42
    Benzamide compounds
    Recurium IP Holding, LLC
    09/05/22
  687. 69
    Benzopyrazole compound used as RHO kinase inhibitor
    MEDSHINE DISCOVERY INC.
    09/05/22
  688. 280
    Inhibitors of fibroblast growth factor receptor kinases
    KINNATE BIOPHARMA INC.
    09/05/22
  689. 9
    KRAS mutant protein inhibitors
    JACOBIO PHARMACEUTICALS CO., LTD.
    09/05/22
  690. 137
    Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
    SHIONOGI & CO., LTD.
    09/05/22
  691. 43
    PGDH inhibitors and methods of making and using
    MYOFORTE THERAPEUTICS, INC.
    09/05/22
  692. 128
    Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    09/05/22
  693. 20
    Quaternary lactam compound and pharmaceutical use thereof
    SHANGHAI MEIYUE BIOTECH DEVELOPMENT CO., LTD.
    09/05/22
  694. 64
    Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
    Guangzhou Innocare Pharma Tech Co., Ltd.
    09/05/22
  695. 2
    Substituted pyrazolopyrimidines useful as kinases inhibitors
    Teligene Ltd.
    09/05/22
  696. 31
    4H-pyrrolo[3,2-c]pyridin-4-one derivatives
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; Dana-Farber Cancer Institute, Inc.; The Broad Institute, Inc.
    08/29/22
  697. 75
    Aliphatic acid amide derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    08/29/22
  698. 35
    Glycoside derivatives and uses thereof
    Novartis AG
    08/29/22
  699. 52
    Imidazole and triazole containing bicyclic compounds as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    08/29/22
  700. 55
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    08/29/22
  701. 33
    Substituted piperidines as kinase inhibitors
    Daewoong Pharmaceutical Co., Ltd.
    08/29/22
  702. 207
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon Inc.
    08/28/22
  703. 34
    Dopamine D3 receptor selective antagonists/partial agonists and uses thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    08/28/22
  704. 466
    Heteroaryl Rheb inhibitors and uses thereof
    NAVITOR PHARMACEUTICALS, INC.
    08/28/22
  705. 266
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    08/28/22
  706. 34
    Identification of stabilizers of multimeric proteins
    Leland Stanford Junior University
    08/28/22
  707. 28
    Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    08/28/22
  708. 11
    hTRPV1 chemical agents
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    08/28/22
  709. 12
    CD73 inhibitors and therapeutic uses thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/21/22
  710. 22
    Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
    KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    08/21/22
  711. 33
    Inhibitors of lysine gingipain
    CORTEXYME, INC.
    08/21/22
  712. 42
    MAGL inhibitors
    H. LUNDBECK A/S
    08/21/22
  713. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    08/21/22
  714. 30
    Substituted pyrazolo[3,4-d]pyrimidines as Wee1 inhibitors
    NUVATION BIO INC.
    08/21/22
  715. 19
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    08/15/22
  716. 203
    CD73 inhibitors
    ORIC PHARMACEUTICALS, INC.
    08/15/22
  717. 26
    CaMKII inhibitors and uses thereof
    The Johns Hopkins University
    08/15/22
  718. 32
    Chemical compounds
    ASTRAZENECA AB
    08/15/22
  719. 68
    Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase
    The Governors of the University of Alberta
    08/15/22
  720. 18
    Optically active crosslinked cyclic secondary amine derivative
    Sumitomo Dainippon Pharma Co., Ltd.
    08/15/22
  721. 134
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    08/15/22
  722. 22
    Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
    VALO HEALTH, INC.
    08/15/22
  723. 26
    Combination therapy for treatment of hematological diseases
    Incyte Corporation
    08/14/22
  724. 67
    Ketone inhibitors of lysine gingipain
    CORTEXYME, INC.
    08/14/22
  725. 42
    Benzamide compounds
    Recurium IP Holdings, LLC
    08/07/22
  726. 147
    Cyanopyrrolidines as dub inhibitors for the treatment of cancer
    MISSION THERAPEUTICS LIMITED
    08/07/22
  727. 415
    Inhibitors of Bruton's tyrosine kinase and methods of their use
    Janssen Pharmaceutica NV
    08/07/22
  728. 22
    Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
    Temple University—Of The Commonwealth System of Higher Education; Praeventix, LLC
    08/07/22
  729. 121
    Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    08/07/22
  730. 708
    Substituted carboxamides as inhibitors of WDR5 protein-protein binding
    Propellon Therapeutics Inc.
    08/07/22
  731. 18
    Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer
    JUBILANT BIOSYS LIMITED
    08/07/22
  732. 173
    9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
    Merck Sharp & Dohme Corp.
    08/06/22
  733. 61
    9H-pyrrolo-dipyridine derivatives
    TBA
    08/06/22
  734. 410
    Azabenzimidazoles and their use as AMPA receptor modulators
    Janssen Pharmaceutica NV
    08/06/22
  735. 17
    Ghrelin O-acyltransferase inhibitors
    Glaxosmithkline Intellectual Property Development Limited
    08/06/22
  736. 46
    Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/06/22
  737. 113
    Hsp90 inhibitors and uses thereof
    TRUSTEES OF BOSTON UNIVERSITY; The Governing Council of the University of Toronto
    08/06/22
  738. 91
    Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors
    Pfizer Inc.
    08/06/22
  739. 20
    Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
    FORMA Therapeutics, Inc.
    08/06/22
  740. 177
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences, Inc.
    08/06/22
  741. 375
    Macrocyclic flu endonuclease inhibitors
    Janssen BioPharma, Inc.
    08/06/22
  742. 19
    Morpholine derivative
    Hoffmann-La Roche Inc.
    08/06/22
  743. 83
    Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
    Merck Sharp & Dohme Corp.
    08/06/22
  744. 6
    Protease inhibitors
    Medivir AB
    08/06/22
  745. 182
    Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases
    THE ROCKEFELLER UNIVERSITY
    08/06/22
  746. 63
    Pyrazole compound
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    08/06/22
  747. 193
    Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
    Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
    08/06/22
  748. 37
    Thienodiazepine derivatives and application thereof
    CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
    08/06/22
  749. 54
    Treatment of GVHD
    KADMON CORPORATION, LLC; REGENTS OF THE UNIVERSITY OF MINNESOTA
    08/06/22
  750. 78
    4,6 dihydropyrrolo [3,4-C] pyrazole-5 (1H)-carbonitrile derivates for treating cancer
    MISSION THERAPEUTICS LIMITED
    08/01/22
  751. 25
    Cyano thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute, Inc.
    08/01/22
  752. 23
    Inhibitors of KRAS G12C and methods of using the same
    AMGEN INC.
    08/01/22
  753. 47
    Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
    Venenum Biodesign, LLC
    08/01/22
  754. 85
    3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
    Incyte Corporation
    07/31/22
  755. 22
    Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
    Oligomerix, Inc.
    07/31/22
  756. 29
    Heterocyclic compounds as adenosine antagonists
    Nuvation Bio Inc.
    07/31/22
  757. 176
    Phenylacetamides as inhibitors of rock
    Bristol-Myers Squibb Company
    07/31/22
  758. 475
    Piperidine CXCR7 receptor modulators
    IDORSIA PHARMACEUTICALS LTD.
    07/31/22
  759. 52
    Substituted quinazolines for inhibiting kinase activity
    NEUPHARMA, INC.
    07/31/22
  760. 213
    Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors
    Boehringer Ingelheim International GmbH
    07/31/22
  761. 26
    Treatment of hidradenitis suppurativa using JAK inhibitors
    Incyte Corporation
    07/31/22
  762. 156
    2-arylsulfonamido-N-arylacetamide derivatized STAT3 inhibitors
    University of Hawaii
    07/28/22
  763. 83
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    07/24/22
  764. 47
    Benzimidazole and indole compounds and uses thereof
    Incyte Corporation
    07/24/22
  765. 10
    Chemical compounds
    GlaxoSmithKline Intellectual Property (No. 2) Limited
    07/24/22
  766. 66
    Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
    Bristol-Myers Squibb Company
    07/24/22
  767. 108
    Heterocyclic compounds and uses thereof
    Nuvation Bio Inc.
    07/24/22
  768. 27
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D IP, LLC
    07/24/22
  769. 24
    Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    UNION therapeutics A/S
    07/24/22
  770. 1
    Combination therapy involving diaryl macrocyclic compounds
    TURNING POINT THERAPEUTICS, INC.
    07/21/22
  771. 3
    Composition for inhibiting growth of SARS-CoV-2 and method of preparing the same
    Medicare Pharmaceuticals Inc.; MEDICARE LC.
    07/21/22
  772. 37
    Diarylhydantoin compounds and methods of use thereof
    Nuvation Bio Inc.
    07/21/22
  773. 237
    Heterocyclic inhibitors of MCT4
    Vettore, LLC
    07/21/22
  774. 18
    Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
    Hanmi Pharm. Co., Ltd.
    07/21/22
  775. 184
    Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
    REATA PHARMACEUTICALS, INC.
    07/21/22
  776. 171
    RAD51 inhibitors
    Cyteir Therapeutics, Inc.
    07/21/22
  777. 16
    Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    UNION THERAPEUTICS A/S
    07/21/22
  778. 256
    Substituted piperidine compound and use thereof
    TAKEDA PHARMACEUTICAL COMPANY LIMITED
    07/21/22
  779. 781
    Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
    FORMA Therapeutics, Inc.
    07/21/22
  780. 82
    Tricyclic CRBN ligands and uses thereof
    KYMERA THERAPEUTICS, INC.
    07/21/22
  781. 32
    Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
    Daegu-Gyeongbuk Medical Innovation Foundation; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; Kyungpook National University Industry-Academic Cooperation Foundation
    07/16/22
  782. 1775
    EIF4E-inhibiting compounds and methods
    eFFECTOR Therapeutics, Inc.
    07/16/22
  783. 33
    Macrocyclic fluorine substituted indole derivatives
    The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    07/16/22
  784. 390
    Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
    Incyte Corporation; Incyte Holdings Cororation
    07/16/22
  785. 6
    Pyrrolidine compounds
    Eli Lilly and Company
    07/16/22
  786. 369
    Substituted piperazines as KRAS G12C inhibitors
    AMGEN INC.
    07/16/22
  787. 9
    AMPK activators
    KALLYOPE, INC.
    07/10/22
  788. 51
    Aromatic derivative, preparation method for same, and medical applications thereof
    BIOARDIS LLC
    07/10/22
  789. 19
    Compound as selective JAK inhibitor, and salt and therapeutic use thereof
    Suzhou Longbiotech Pharmaceuticals Co., Ltd.
    07/10/22
  790. 435
    Compounds and compositions for the inhibition of NAMPT
    Valo Health, Inc.; Genentech, Inc.
    07/10/22
  791. 9
    Enantiomers of substituted thiazoles as antiviral compounds
    Innovative Molecules GmbG
    07/10/22
  792. 229
    Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
    APTOSE BIOSCIENCES INC.
    07/10/22
  793. 41
    Inhibitors of RET
    BLUEPRINT MEDICINES CORPORATION
    07/10/22
  794. 61
    Macrocyclic compounds that inhibit MCL-1 protein
    AMGEN INC.
    07/10/22
  795. 63
    Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
    TBA
    07/10/22
  796. 171
    Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists
    AMGEN INC.
    07/05/22
  797. 291
    Colony stimulating factor-1 receptor (CSF-1R) inhibitors
    GENZYME CORPORATION
    07/05/22
  798. 28
    Tricyclic compounds for use in treatment of proliferative disorders
    ARGONAUT THERAPEUTICS LIMITED
    07/05/22
  799. 32
    Cyclopentane compounds
    Dizal (Jiangsu) Pharmaceutical Co., Ltd.
    07/04/22
  800. 55
    MAPK inhibitors
    EverBrilliant Pharma Pty Ltd
    07/04/22
  801. 16
    Modulators of methyl modifying enzymes, compositions and uses thereof
    Constellation Pharmaceuticals, Inc.
    07/04/22
  802. 375
    P300/CBP HAT inhibitors
    Constellation Pharmaceuticals, Inc.
    07/04/22
  803. 34
    Pharmaceutical composition for ANO1 antagonist with anticancer activity
    INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY
    07/04/22
  804. 1
    Aminopyrimidine compound and composition comprising same and use thereof
    Shenzhen TargetRx, Inc.
    06/26/22
  805. 14
    Benzamide derivatives as PPAR-gamma modulators
    Medibiofarma, S.L.
    06/26/22
  806. 48
    Carbocyclic prolinamide derivatives
    ORION OPHTHALMOLOGY LLC
    06/26/22
  807. 19
    Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof
    SHANGHAI RINGENE BIOPHARMA CO., LTD.
    06/26/22
  808. 1
    Indazole compound for use in inhibiting kinase activity, composition and application thereof
    Shenzhen TargetRx, Inc.
    06/26/22
  809. 224
    Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
    IDORSIA PHARMACEUTICALS LTD
    06/26/22
  810. 17
    Maslinic and oleanolic acids derivatives for treating SARS-CoV-2 infection
    KING ABDULAZIZ UNIVERSITY
    06/26/22
  811. 105
    Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
    Array BioPharma Inc.
    06/26/22
  812. 331
    Small molecule inhibitors of galectin-3
    Bristol-Myers Squibb Company
    06/26/22
  813. 3
    Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1′,2′:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having HIV integrase inhibitory activity
    SHIONOGI & CO., LTD.; VIIV HEALTHCARE COMPANY
    06/26/22
  814. 516
    Triaryl compounds for treatment of PD-L1 diseases
    ChemoCentryx, Inc.
    06/26/22
  815. 14
    Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
    Jubilant Biosys Limited
    06/26/22
  816. 73
    19-NOR neuroactive steroids and methods of use thereof
    Sage Therapeutics, Inc.
    06/24/22
  817. 15
    Aromatic compound, pharmaceutical composition and use thereof
    Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
    06/24/22
  818. 587
    Biaryl derivative as GPR120 agonist
    LG CHEM. LTD.
    06/24/22
  819. 53
    Bicyclic heterocyclic derivatives
    Merck Patent GmbH
    06/24/22
  820. 48
    Dihydropyrimidine compounds and uses thereof in medicine
    SUNSHINE LAKE PHARMA CO., LTD.
    06/24/22
  821. 205
    Imidazotriaines and imidazopyrimidines as kinase inhibitors
    INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
    06/24/22
  822. 51
    Sulfoximine glycosidase inhibitors
    Asceneuron SA
    06/24/22
  823. 126
    TRPV4 antagonists
    GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
    06/24/22
  824. 41
    [1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors
    Boehringer Ingelheim International GmbH
    06/24/22
  825. 9
    1,8-naphthyridinone compounds and uses thereof
    NUVATION BIO INC.
    06/19/22
  826. 637
    Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor
    Corvus Pharmaceuticals, Inc.
    06/19/22
  827. 11
    Fused imidazo-piperidine JAK inhibitors
    THERAVANCE BIOPHARMA R&D IP, LLC
    06/19/22
  828. 72
    Pyrazole derivative compound and use thereof
    HANMI PHARM. CO., LTD.
    06/19/22
  829. 371
    Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
    Pfizer Inc.
    06/19/22
  830. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    06/19/22
  831. 45
    Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
    CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
    06/19/22
  832. 71
    3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
    Ludwig Institute for Cancer Research Ltd
    06/17/22
  833. 22
    Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
    TES PHARMA S.R.L.
    06/17/22
  834. 43
    N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
    Korea Research Institute of Chemical Technology
    06/17/22
  835. 409
    Substituted bicyclic compounds as farnesoid X receptor modulators
    Bristol-Myers Squibb Company
    06/17/22
  836. 3
    Triple combination of pure 5-HT6 receptor antagonists, acetylcholinesterase inhibitors and NMDA receptor antagonist
    Suven Life Sciences Limited
    06/17/22
  837. 508
    Bicyclic fused pyridine compounds as inhibitors of TAM kinases
    ARRAY BIOPHARMA INC
    06/13/22
  838. 114
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
    University of Washington through its Center for Commercialization
    06/13/22
  839. 69
    Compounds and methods for inhibiting JAK
    Dizal (Jiangsu) Pharmaceutical Co., Ltd.
    06/13/22
  840. 116
    Cyclopropylamines as LSD1 inhibitors
    Incyte Corporation
    06/13/22
  841. 11
    FXR (NR1H4) modulating compounds
    Gilead Sciences, Inc.
    06/13/22
  842. 63
    Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof
    SHANGHAI DE NOVO PHARMATECH CO., LTD.
    06/13/22
  843. 4
    Metalloenzyme inhibitor compounds
    Mycovia Pharmaceuticals, Inc.
    06/13/22
  844. 288
    PCSK9 inhibitors and methods of use thereof
    AstraZeneca AB
    06/13/22
  845. 157
    Phenyl indole allosteric inhibitors of P97 ATPase
    University of Pittsburgh—Of the Commonwealth System of Higher Education; National Institutes of Health, A Component of the U.S. Department of Hearth and Human Services; The Regents of the University of California
    06/13/22
  846. 3
    Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing same
    ONCOBIX CO., LTD.
    06/13/22
  847. 34
    Quinazoline and indole compounds to treat medical disorders
    Achillion Pharmaceuticals, Inc.
    06/13/22
  848. 172
    Therapeutic compounds and uses thereof
    GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
    06/13/22
  849. 52
    Tricyclic inhibitors of poly(ADP-ribose)polymerase
    Rakovina Therapeutics Inc.
    06/13/22
  850. 510
    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    06/12/22
  851. 86
    (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
    Genentech, Inc.
    06/10/22
  852. 12
    2-phenyl-3,4-dihydropyrrolo[2,1-Ff] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
    TOPADUR PHARMA AG
    06/10/22
  853. 134
    Compounds useful for treating gastrointestinal tract disorders
    ARDELYX, INC.
    06/10/22
  854. 2
    Ethynyl derivatives
    Hoffmann-La Roche Inc.
    06/10/22
  855. 56
    Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    06/10/22
  856. 174
    Proteasome activity enhancing compounds
    Proteostasis Therapeutics, Inc.
    06/10/22
  857. 76
    Pyrazolopyridine compounds and uses thereof
    Incyte Corporation
    06/10/22
  858. 90
    Spirocyclic ROR-gamma modulators
    ESCALIER BIOSCIENCES B.V.
    06/10/22
  859. 61
    Sulfonimidoylpurinone compounds and methods of treatment using the same
    Hoffmann-La Roche Inc.
    06/10/22
  860. 98
    Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof
    ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
    06/10/22
  861. 6
    Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
    LANDSTEINER GENMED, S.L.
    06/09/22
  862. 1
    Formulations of an AXL/MER inhibitor
    Incyte Corporation
    06/09/22
  863. 21
    Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2(HDAC1-2)
    Medibiofarma, S.L.
    06/09/22
  864. 95
    Inhibitors of plasma kallikrein
    Kalvista Pharmaceuticals Limited
    06/09/22
  865. 4
    Organosilicon carriers for use in treating infections and/or diseases caused by SARS viruses
    TBA
    06/09/22
  866. 3
    Aminobenzimidazole derivatives, treatments, and methods of inhibiting histone deacetylase
    Translational Drug Development, LLC
    06/06/22
  867. 274
    Combination of isoindolinone derivatives with SGI-110
    ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
    06/06/22
  868. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    06/06/22
  869. 99
    Fused ring compounds
    Genentech, Inc.
    06/06/22
  870. 134
    Isoxazole compounds as inhibitors of heat shock proteins
    Cancer Research Technology Limited; The Institute of Cancer Research; Vernalis (R&D) Limited
    06/06/22
  871. 197
    KIF18A inhibitors
    AMGEN INC.
    06/06/22
  872. 8
    Morpholine derivates as inhibitors of Vps34
    Neuropore Therapies, Inc.
    06/06/22
  873. 77
    Protein kinase B inhibitors
    ASTRAZENECA AB
    06/06/22
  874. 116
    Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
    MISSION THERAPEUTICS LIMITED
    06/06/22
  875. 183
    Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators
    Genentech, Inc.
    06/06/22
  876. 6
    Substituted pyrrolopyridines as ATR inhibitors
    BlueValley Pharmaceutical LLC
    06/06/22
  877. 36
    Substituted sulfoximine compounds
    Cadila Healthcare Limited
    06/06/22
  878. 11
    2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
    CrystalGenomics, Inc.
    05/30/22
  879. 166
    KDM1A inhibitors for the treatment of disease
    Imago Biosciences, Inc.
    05/30/22
  880. 99
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme Corp.
    05/30/22
  881. 244
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    05/29/22
  882. 128
    Myocyte enhancer factor 2 (MEF2) modulators
    STANDARD LLC
    05/29/22
  883. 32
    Selective androgen receptor degrader (SARD) ligands and methods of use thereof
    UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    05/29/22
  884. 38
    Substituted tetrahydroquinolinone compounds as ROR gamma modulators
    AURIGENE DISCOVERY TECHNOLOGIES LIMITED
    05/29/22
  885. 108
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    05/29/22
  886. 15
    Bicyclic inhibitors of histone deacetylase
    Alkermes, Inc.
    05/22/22
  887. 812
    Compounds that inhibits MCL-1 protein
    AMGEN INC.
    05/22/22
  888. 18
    Heterocycles useful as anti-cancer agents
    Hangzhou Innogate Pharma Co., Ltd.
    05/22/22
  889. 275
    Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
    Whitehead Institute for Biomedical Research; Dana-Farber Cancer Institute, Inc.; The United States of America, as represented by the Secretary, Department of Health and Human Services
    05/22/22
  890. 10
    Substituted pyridines as inhibitors of histone deacetylase
    Alkermes, Inc.
    05/22/22
  891. 122
    Tertiary alcohols as PI3K-γ inhibitors
    Incyte Corporation
    05/22/22
  892. 16
    5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
    Temple University-Of the Commonwealth System of Higher Education
    05/14/22
  893. 137
    Cyclin dependent kinase inhibitors
    Pfizer Inc.
    05/14/22
  894. 333
    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    05/14/22
  895. 23
    Pyridylpyridone compounds
    Sprint Bioscience AB
    05/14/22
  896. 30
    Pyrrole tricyclic compounds as A2A / A2B inhibitors
    Incyte Corporation
    05/14/22
  897. 71
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    05/14/22
  898. 218
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    MIRATI THERAPEUTICS, INC.
    05/14/22
  899. 93
    Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors
    PFIZER INC.
    05/14/22
  900. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    05/14/22
  901. 4
    2,3-dihydrofuro[2,3-b]pyridine compounds
    Eli Lilly and Company
    05/08/22
  902. 42
    Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    05/08/22
  903. 17
    Cannabinoid receptor modulators
    Arena Pharmaceuticals, Inc.
    05/08/22
  904. 88
    Compositions for treating neurodegenerative diseases
    Cognition Therapeutics, Inc.
    05/08/22
  905. 341
    Compound, compositions, and methods
    DENALI THERAPEUTICS INC.
    05/08/22
  906. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    SHY Therapeutics LLC
    05/08/22
  907. 103
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    05/08/22
  908. 52
    Indoleamine 2,3-dioxygenase inhibitor, method for preparation and use thereof
    NANJING HUAWE MEDICINE TECHNOLOGY GROUP CO., LTD.
    05/08/22
  909. 21
    Linear glycosidase inhibitors
    Asceneuron SA
    05/08/22
  910. 42
    MAGL inhibitors
    H. LUNDBECK A/S
    05/08/22
  911. 16
    Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors
    Boehringer Ingelheim International GmbH
    05/08/22
  912. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics, Incorporated
    05/08/22
  913. 52
    Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    05/08/22
  914. 7
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica NV
    05/08/22
  915. 32
    Compositions and methods for treating parasitic diseases
    The Regents of the University of California; Washington University
    05/03/22
  916. 109
    Compounds useful as inhibitors of ALCAT 1
    PERENNA PHARMACEUTICALS, INC.
    05/03/22
  917. 80
    Ectonucleotidase inhibitors and methods of use thereof
    CALITHERA BIOSCIENCES, INC.
    05/03/22
  918. 5
    Nitrogenous tricyclic compounds and uses thereof in medicine
    SUNSHINE LAKE PHARMA CO., LTD.
    05/03/22
  919. 31
    Prognostic biomarkers for TTK inhibitor chemotherapy
    NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    05/03/22
  920. 20
    Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
    Sprint Bioscience AB
    05/03/22
  921. 121
    Pyridone derivatives having tetrahydropyranylmethyl groups
    Daiichi Sankyo Company, Limited
    05/03/22
  922. 41
    Selective inhibitors of protein arginine methytransterase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    05/03/22
  923. 53
    Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
    Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
    05/03/22
  924. 376
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    05/03/22
  925. 20
    1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
    Incyte Corporation; Incyte Holdings Corporation
    05/02/22
  926. 119
    3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
    ALLERGAN, INC.
    05/02/22
  927. 96
    Certain chemical entities, compositions, and methods
    NEUPHARMA, INC
    05/02/22
  928. 27
    HDAC6 inhibitors and imaging agents
    The General Hospital Corporation
    05/02/22
  929. 55
    Indole derivatives and their use as protein kinase inhibitors
    RESPIVERT LIMITED
    05/02/22
  930. 204
    Metallo-beta-lactamase inhibitors and methods of use thereof
    Merck Sharp & Dohme Corp.
    05/02/22
  931. 117
    NLRP3 inflammasome inhibitors
    Novartis AG
    05/02/22
  932. 595
    Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    05/02/22
  933. 526
    Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    05/02/22
  934. 1
    Sulfinylpyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    05/02/22
  935. 243
    Triazolopyrimidine compounds and uses thereof
    Novartis AG
    05/02/22
  936. 28
    Anti-proliferative agents for treating PAH
    Pfizer Inc.
    04/29/22
  937. 13
    Aza-indazole compounds for use in tendon and/or ligament injuries
    NOVARTIS AG
    04/29/22
  938. 247
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    04/29/22
  939. 37
    Iridinesulfonamide compound and use method thereof
    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
    04/29/22
  940. 281
    Kinase inhibitors and uses thereof
    DENALI THERAPEUTICS INC.
    04/29/22
  941. 14
    Personal care compositions comprising fatty acid amide derivatives
    Conopco, Inc.
    04/29/22
  942. 302
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences, Inc.
    04/29/22
  943. 100
    Sulfonamides as modulators of sodium channels
    VERTEX PHARMACEUTICALS INCORPORATED
    04/29/22
  944. 19
    Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
    The Broad Institute, Inc.; Biogen MA Inc.
    04/29/22
  945. 56
    Compounds targeting PRMT5
    Aligos Therapeutics, Inc.
    04/25/22
  946. 573
    Fused ring derivative having MGAT-2 inhibitory activity
    SHIONOGI & CO., LTD.
    04/25/22
  947. 113
    Aminopyrimidinyl compounds
    Pfizer Inc.
    04/24/22
  948. 16
    Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
    GLYCOMIMETICS. INC.
    04/24/22
  949. 115
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics, Inc.
    04/24/22
  950. 92
    N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    04/24/22
  951. 13
    Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    BioAxone BioSciences, Inc.
    04/24/22
  952. 30
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University-Of The Commonwealth System of Higher Education
    04/17/22
  953. 111
    Alkyl substituted triazole compounds as agonists of the APJ Receptor
    AMGEN INC.
    04/17/22
  954. 377
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica NV
    04/17/22
  955. 8
    Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
    THE JOHNS HOPKINS UNIVERSITY
    04/17/22
  956. 44
    Heterocyclic compounds for the inhibition of PASK
    BioEnergenix LLC
    04/17/22
  957. 246
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    04/17/22
  958. 36
    N-aryl oxamic acids
    Purdue Research Foundation
    04/17/22
  959. 6
    Pyrazoloquinazolinone antitumor agents
    The Rockefeller University
    04/17/22
  960. 43
    Quinoline compounds as modulators of RAGE activity and uses thereof
    TBA
    04/17/22
  961. 4
    Quinolone compounds as inhibitors of the BCL6 BTB domain protein-protein interaction and/or as BCL6 degraders
    ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
    04/17/22
  962. 68
    Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
    Nuvation Bio Inc.
    04/17/22
  963. 88
    6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
    SPRINT BIOSCIENCE AB
    04/10/22
  964. 73
    6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative
    AYUMI PHARMACEUTICAL CORPORATION
    04/10/22
  965. 40
    Amino pyrimidine derivatives
    Novartis AG
    04/10/22
  966. 46
    Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors
    ARIAD Pharmaceuticals, Inc.
    04/10/22
  967. 14
    Azaspiro[4.5]decane derivatives and use thereof
    Purdue Pharma L.P.
    04/10/22
  968. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating disease conditions, including metabolic disorders and cancers
    Jenrin Discovery, LLC
    04/10/22
  969. 32
    Compound as ACC inhibitor and use thereof
    NANJING SANHOME PHARMACEUTICAL CO., LTD.
    04/10/22
  970. 161
    Compounds for the treatment of pain
    TBA
    04/10/22
  971. 4
    Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor
    Incyte Corporation
    04/10/22
  972. 95
    Cyanoindoline derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    04/10/22
  973. 145
    Imidazopyrimidine derivatives
    Gilead Sciences, Inc.
    04/10/22
  974. 38
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme Corp.
    04/10/22
  975. 59
    Pyrazole derivatives as plasma kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    04/10/22
  976. 130
    Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors
    Aurigene Discovery Technologies Limited
    04/10/22
  977. 23
    Somatostatin modulators and uses thereof
    CRINETICS PHARMACEUTICALS, INC.
    04/10/22
  978. 562
    Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors
    Dart Neuroscience, (Cayman) LTD.
    04/10/22
  979. 183
    Substituted amino acids as integrin inhibitors
    Pliant Therapeutics, Inc.
    04/10/22
  980. 254
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    04/10/22
  981. 6
    Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
    Shenzhen TargetRx, Inc.
    04/10/22
  982. 35
    Therapeutic heterocyclic compounds
    Gilead Sciences, Inc.
    04/10/22
  983. 212
    Vasopressin receptor antagonists and products and methods related thereto
    BLACKTHORN THERAPEUTICS, INC.
    04/10/22
  984. 13
    [1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives
    ELI LILLY AND COMPANY
    04/10/22
  985. 27
    3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
    Novartis AG
    04/09/22
  986. 50
    Methods for modulating taste receptors
    MARS, INCORPORATED
    04/09/22
  987. 64
    Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Vertex Pharmaceuticals Incorporated
    04/09/22
  988. 164
    Non-fused tricyclic compounds
    VIVACE THERAPEUTICS, INC.
    04/09/22
  989. 45
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb Company
    04/09/22
  990. 73
    4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
    Takeda Pharmaceutical Company Limited
    04/03/22
  991. 8
    Adrenergic receptor modulating compounds and methods of using the same
    The Board of Trustees of the Leland Stanford Junior University
    04/03/22
  992. 17
    Aniline-substituted 1,2-dihydropyrrol[3,4-C]pyridin/pyrimidin-3-one derivative and use thereof
    YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.; SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.
    04/03/22
  993. 333
    Benzenesulfonamide compouds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    04/03/22
  994. 124
    Benzimidazole compounds and derivatives as EGFR inhibitors
    Boehringer Ingelheim International GmbH
    04/03/22
  995. 187
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    04/03/22
  996. 59
    Compositions and methods to modulate chloride ion channel activity
    The Board of Trustees of the Leland Stanford Junior University
    04/03/22
  997. 18
    Compounds, compositions and methods
    Denali Therapeutics Inc.
    04/03/22
  998. 133
    Heterocyclic compounds as kinase inhibitors
    NUVATION BIO INC.
    04/03/22
  999. 29
    Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme Corp.
    04/03/22
  1000. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    BioSplice Therapeutics, Inc.
    04/03/22
  1001. 7
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    04/03/22
  1002. 126
    Substituted carboxamides as inhibitors of WDR5 protein-protein binding
    Propellon Therapeutics Inc.
    04/03/22
  1003. 89
    Substituted heterocyclyl derivatives as CDK inhibitors
    Aurigene Discovery Technologies Limited
    04/03/22
  1004. 19
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    04/03/22
  1005. 5
    Matriptase inhibitors and uses thereof
    SOCIÉTÉ DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C.
    03/30/22
  1006. 11
    3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman) Limited
    03/27/22
  1007. 71
    3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
    Board of Trustees of the Southern Illinois University
    03/27/22
  1008. 20
    4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    03/27/22
  1009. 173
    ASK1 inhibiting agents
    BIOGEN MA INC.
    03/27/22
  1010. 13
    Amino-triazolopyridine compounds and their use in treating cancer
    AstraZeneca AB
    03/27/22
  1011. 135
    Bicyclic heteroaryl compounds and uses thereof
    Revolution Medicines, Inc.
    03/27/22
  1012. 35
    CXCR2 antagonist
    MEDSHINE DISCOVERY INC.
    03/27/22
  1013. 34
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    03/27/22
  1014. 67
    Dynamin-1-like protein inhibitors
    Mitobridge, Inc.
    03/27/22
  1015. 10
    Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
    The Texas A&M University System
    03/27/22
  1016. 34
    Fused pyrimidine derivatives as A2A / A2B inhibitors
    Incyte Corporation
    03/27/22
  1017. 25
    Fused ring derivative used as FGFR4 inhibitor
    JACOBIO PHARMACEUTICALS CO., LTD.
    03/27/22
  1018. 214
    Heteroaromatic derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    03/27/22
  1019. 6
    Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    03/27/22
  1020. 8
    Indane-amines as PD-L1 antagonists
    ChemoCentryx, Inc.
    03/27/22
  1021. 66
    Inhibitors of Plasma Kallikrein and uses thereof
    Takeda Pharmaceutical Company Limited
    03/27/22
  1022. 42
    Inhibitors of dihydroceramide desaturase for treating disease
    Centaurus Therapeutics
    03/27/22
  1023. 55
    Inhibitors of integrated stress response pathway
    PRAXIS BIOTECH LLC
    03/27/22
  1024. 118
    JAK inhibitors
    VIMALAN BIOSCIENCES, INC.
    03/27/22
  1025. 77
    Macrocycles as factor XIA inhibitors
    Bristol-Myers Squibb Company
    03/27/22
  1026. 42
    Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International GmbH
    03/27/22
  1027. 56
    Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
    TBA
    03/27/22
  1028. 95
    Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    03/27/22
  1029. 7
    Pyrrolopyrimidine and pyrrolopyridine derivatives
    GALAPAGOS NV
    03/27/22
  1030. 96
    Pyrrolopyrimidine derivatives as TAM inhibitors
    Incyte Corporation
    03/27/22
  1031. 239
    Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    03/27/22
  1032. 38
    Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
    Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
    03/27/22
  1033. 115
    Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
    Array BioPharma Inc.
    03/27/22
  1034. 125
    Therapeutic compounds and uses thereof
    GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
    03/27/22
  1035. 135
    Thienopyridine inhibitors of RIPK2
    Celgene Corporation
    03/27/22
  1036. 22
    Thienopyrimidones
    Boehringer Ingelheim International GmbH
    03/27/22
  1037. 186
    2-quinolone derived inhibitors of BCL6
    The Institute of Cancer Research: Royal Cancer Hospital; Cancer Research Technology Limited
    03/20/22
  1038. 15
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    03/20/22
  1039. 37
    Cyclic substituted imidazo[4,5-c]quinoline derivatives
    PFIZER INC.
    03/20/22
  1040. 113
    Fused pyrazine derivatives as A2A / A2B inhibitors
    Incyte Corporation
    03/20/22
  1041. 13
    Heterocyclic derivatives as PI3K inhibitors
    Incyte Corporation
    03/20/22
  1042. 33
    Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    03/20/22
  1043. 77
    Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme Corp.
    03/20/22
  1044. 6
    Inhibiting the transient receptor potential al ion channel
    Eli Lilly and Company
    03/20/22
  1045. 44
    Inhibitors of NEK7 kinase
    HALIA THERAPEUTICS, INC.
    03/20/22
  1046. 530
    Purinones as ubiquitin-specific protease 1 inhibitors
    FORMA Therapeutics, Inc.
    03/20/22
  1047. 48
    Pyridinone derivatives and their use as selective ALK-2 inhibitors
    NOVARTIS AG
    03/20/22
  1048. 76
    Sting agonists
    VENENUM BIODESIGN, LLC
    03/20/22
  1049. 97
    Tricyclic fused thiophene derivatives as JAK inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    03/20/22
  1050. 71
    4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives and uses thereof
    SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
    03/13/22
  1051. 4
    Amide derivatives as Nav1.7 and Nav1.8 blockers
    RaQualia Pharma Inc.
    03/13/22
  1052. 66
    Antagonists of the muscarinic acetylcholine receptor M4
    Vanderbilt University
    03/13/22
  1053. 13
    C7 substituted oxysterols and methods of use thereof
    SAGE THERAPEUTICS, INC.
    03/13/22
  1054. 2
    Crystal form of urate transporter 1 inhibitor and preparation method and use thereof
    TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.
    03/13/22
  1055. 129
    Cyclopropylamines as LSD1 inhibitors
    Incyte Corporation
    03/13/22
  1056. 30
    Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
    TOPADUR PHARMA AG
    03/13/22
  1057. 35
    Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor
    InflaRx GmbH
    03/13/22
  1058. 38
    Fused triazole agonists of the APJ receptor
    Amgen Inc.
    03/13/22
  1059. 57
    Heterocycle comprising tyrosine kinase inhibitors
    Principia Biopharma Inc.
    03/13/22
  1060. 46
    MAP kinase modulators and uses thereof
    The Trustees of Columbia University in the City of New York; Northwestern University
    03/13/22
  1061. 157
    Oxysterols and methods of use thereof
    SAGE THERAPEUTICS, INC.
    03/13/22
  1062. 1
    Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
    Arena Pharmaceuticals, Inc.
    03/13/22
  1063. 37
    Pyrazole MAGL inhibitors
    H. LUNDBECK A/S
    03/13/22
  1064. 140
    Pyrazolopyrimidine compounds and methods of use thereof
    Genentech, Inc.
    03/13/22
  1065. 17
    Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
    DANA-FARBER CANCER INSTITUTE, INC.
    03/13/22
  1066. 251
    Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
    Sanofi
    03/13/22
  1067. 272
    Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    03/13/22
  1068. 12
    Substituted nucleosides, nucleotides and analogs thereof
    JANSSEN BIOPHARMA, INC.
    03/13/22
  1069. 70
    Substituted triazole derivatives and uses thereof
    Bayer Pharma Aktiengesellschaft
    03/13/22
  1070. 33
    Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
    UNIVERSITÄT DUISBURG-ESSEN
    03/13/22
  1071. 15
    Thrombospondin 1-binding peptide
    DAIICHI SANKYO COMPANY, LIMITED; PEPTIDREAM INC.
    03/13/22
  1072. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    GENUV Inc.
    03/12/22
  1073. 17
    Compositions and methods for treating CNS disorders
    Sage Therapeutics, Inc.
    03/12/22
  1074. 2
    Compounds as neurokinin-1 receptor antagonists and uses thereof
    XWPHARMA LTD.
    03/12/22
  1075. 5
    Methods for treating GI tract disorders
    NEUROGASTRX, INC.
    03/12/22
  1076. 29
    Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
    Aurigene Discovery Technologies Limited
    03/12/22
  1077. 215
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    BAYER AKTIENGELLSCHAFT; BAYER PHARMA AKTIEGELLSCHAFT; THE BROAD INSTITUTE INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    03/08/22
  1078. 715
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCE, INC.
    03/08/22
  1079. 38
    Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Incyte Corporation
    03/08/22
  1080. 15
    Calcium channel inhibitors
    CAVION, INC.
    03/08/22
  1081. 78
    Compounds
    MISSION THERAPEUTICS LIMITED
    03/08/22
  1082. 60
    Dual MAGL and FAAH inhibitors
    Abide Therapeutics, Inc.
    03/08/22
  1083. 66
    Pyridazinone compounds and their use as DAAO inhibitors
    Takeda Pharmaceutical Company Limited
    03/08/22
  1084. 308
    Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein
    Prelude Therapeutics, Incorporated
    03/08/22
  1085. 17
    Substituted 2,3-dihydro-1H-indene analogs and methods using same
    Arbutus Biopharma Corporation
    03/08/22
  1086. 95
    Substituted benzamides as RIPK2 inhibitors
    Boehringer Ingelheim International GmbH
    03/08/22