BDBM176145 US10047103, 178::US9688695, 178

SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(=C)c3cncnc3)cc(OC)cc2o1

InChI Key InChIKey=COJYCUONSGOQJB-UHFFFAOYSA-N

Data  2 EC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 176145   

TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Co.

US Patent
LigandPNGBDBM176145(US10047103, 178 | US9688695, 178)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(=C)c3cncnc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N6O4S2/c1-13(14-7-25-12-26-8-14)22-27-15(11-35-22)10-33-19-4-16(31-2)5-20-17(19)6-21(34-20)18-9-30-23(28-18)36-24(29-30)32-3/h4-9,11-12H,1,10H2,2-3H3
Affinity DataEC50:  0.870nMT: 2°CAssay Description:Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Co.

US Patent
LigandPNGBDBM176145(US10047103, 178 | US9688695, 178)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(=C)c3cncnc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N6O4S2/c1-13(14-7-25-12-26-8-14)22-27-15(11-35-22)10-33-19-4-16(31-2)5-20-17(19)6-21(34-20)18-9-30-23(28-18)36-24(29-30)32-3/h4-9,11-12H,1,10H2,2-3H3
Affinity DataEC50:  0.870nMT: 2°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid