BDBM24226 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine::ASTEMIZOLE::Astemizole, [O-Methyl-3H]::CHEMBL296419::Hismanal::Histaminos::[3H]-ASTEMIZOLE::[3H]Astemizole::cid_2247::med.21724, Compound Astemizole
SMILES COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1
InChI Key InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 67 hits for monomerid = 24226
Affinity DataKi: 2.09nMAssay Description:Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 3nMAssay Description:Binding affinity towards histamine H1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
Affinity DataKi: 95nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 95nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 1.26E+3nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 1.27E+3nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.07E+3nMAssay Description:Displacement of SST14 from human recombinant SST5 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.07E+3nMAssay Description:Displacement of [125I]11-Tyr somatostatin-14 from human SST5R expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 7.94E+3nMAssay Description:Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillat...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of SST14 from human recombinant SST3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of SST14 from human recombinant SST4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of SST14 from human recombinant SST2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.30E+4nMAssay Description:Displacement of FITC-labeled EZH2 peptide from recombinant N-terminal 6His-tagged EED (residues 81 to 441) (unknown origin) expressed in Escherichia ...More data for this Ligand-Target Pair
Affinity DataIC50: 11.5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: >2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bovine)
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibit of purified bovine Farnesyl protein transferase.More data for this Ligand-Target Pair
Affinity DataIC50: 9.38E+4nMAssay Description:Displacement of FITC-labeled EZH2 peptide from recombinant N-terminal 6His-tagged EED (residues 81 to 441) (unknown origin) expressed in Escherichia ...More data for this Ligand-Target Pair
Affinity DataEC50: 4.20E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of hERG potassium channel in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.03nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against Potassium channel HERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance assa...More data for this Ligand-Target Pair
Affinity DataKd: 3.80nMAssay Description:Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.910nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.64E+4nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.912nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair