BDBM50032379 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide::(1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxylic acid diethylamide::CHEMBL99946::LEVOMILNACIPRAN

SMILES CCN(CC)C(=O)[C@]1(C[C@H]1CN)c1ccccc1

InChI Key InChIKey=GJJFMKBJSRMPLA-DZGCQCFKSA-N

Data  2 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50032379   

TargetSodium-dependent serotonin transporter(Rat)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of [3H]-paroxetine binding on serotonin transporter of rat cerebral cortical synaptic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rat)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of Serotonin transporter in cerebral cortical synaptic membrane of rats using [3H]-paroxetineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  420nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  320nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  100nMAssay Description:Inhibition of radiolabeled noradrenaline uptake from rat brain NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  30nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  420nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Human)
Neurocrine Bioscience

Curated by ChEMBL
LigandPNGBDBM50032379((1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclop...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed