BDBM50067040 ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)::(1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one::(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one::(1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione::(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione::(1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione::(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione::1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one::5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one::CHEMBL116438::cid_5281767::curcumin I::curcumine::curcurmin::diferuloylmethane

SMILES: COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O

InChI Key: InChIKey=VFLDPWHFBUODDF-UHFFFAOYSA-N

Data: 18 KI  91 IC50  6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 115 hits for monomerid = 50067040   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase 33 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	710	n/a	n/a	n/a	n/a
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Intestinal-type alkaline phosphatase (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Intestinal-type alkaline phosphatase 1 (Rat)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Intestinal-type alkaline phosphatase (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.41E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Alkaline phosphatase, germ cell type (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Alkaline phosphatase, tissue-nonspecific isozyme (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Toll-like receptor 9 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-lactamase (Pseudomonas aeruginosa)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Amyloid-beta precursor protein (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone deacetylase (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.15E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protease (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (SARS-CoV)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tubulin alpha chain (Sheep)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
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DNA topoisomerase 2-alpha (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tissue factor (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Anthrax toxin receptor 2 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Nitric oxide synthase, inducible (Mouse)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Histone acetyltransferase p300 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2B6 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium two pore domain channel subfamily K member 2 (Bovine)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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17-beta-hydroxysteroid dehydrogenase type 3 (Rat)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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17-beta-hydroxysteroid dehydrogenase type 3 (Rat)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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17-beta-hydroxysteroid dehydrogenase type 3 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cell division protein FtsZ (Bacillus subtilis (strain 168))	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Multidrug resistance protein CDR1 (Yeast)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Multidrug resistance protein CDR1 (Yeast)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Pancreatic triacylglycerol lipase (Pig)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Prostaglandin G/H synthase 1 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Prostaglandin G/H synthase 2 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Acetylcholinesterase (Electric eel)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Integrase (Human immunodeficiency virus type 1)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Prostaglandin G/H synthase 2 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Protein arginine N-methyltransferase 1 [11-371] (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.07E+6	n/a	n/a	n/a	n/a	n/a	n/a
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RmtA (Emericella nidulans)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Polyunsaturated fatty acid 5-lipoxygenase (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Prostaglandin G/H synthase 1 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Nitric oxide synthase, inducible (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Human)	BDBM50067040 (CHEMBL116438 | 1,7-bis(4-hydroxy-3-methoxyphenyl)1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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