BindingDB PrimarySearch

BDBM50069989 (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid::(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid::BORTEZOMIB::CHEMBL325041::Dipeptidyl boronic acid derivative::LDP-341::N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE::PS-341::Peptidyl boronic acid derivative::US11542283, Compound Velcade::Velcade::cid_387447

SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O

InChI Key: InChIKey=GXJABQQUPOEUTA-UHFFFAOYSA-N

Data: 23 KI 101 IC50 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 132 hits for monomerid = 50069989
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.96	n/a	n/a	n/a	n/a	n/a	n/a
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Cystic fibrosis transmembrane conductance regulator (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Proteasome subunit alpha type-6 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.92	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
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Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Proteasome subunit beta type-10 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	940	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325 / PS 47))	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325 / PS 47))	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	2.35E+4	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-1 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-9 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-2 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Proteasome subunit beta type-5 (Human)	BDBM50069989 (CHEMBL325041 \| (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair

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