BDBM50070328 CHEBI:8862::Rilmenidine

SMILES C1CC1C(NC1=NCCO1)C1CC1

InChI Key InChIKey=CQXADFVORZEARL-UHFFFAOYSA-N

Data  13 KI  4 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50070328   

TargetNischarin(RAT)TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  11nMAssay Description:Binding affinity to I1 imidazoline binding site in Rattus norvegicus (rat) PC12 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNischarin(RAT)TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  71nMAssay Description:Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineMore data for this Ligand-Target Pair
In DepthDetails
TargetNischarin(Homo sapiens (Human))
Universit£ Louis Pasteur

Curated by ChEMBL
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]clonidine from imidazoline receptor I-1 of bovine chromaffin cell membranesMore data for this Ligand-Target Pair
TargetNischarin(RAT)TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  83nMAssay Description:Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma countingMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Universit£ de Strasbourg

Curated by ChEMBL
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  182nMAssay Description:Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  288nMAssay Description:Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  6.03E+3nMAssay Description:Binding affinity towards human Alpha-1C adrenergic receptor by the displacement of [3H]prazosinMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  8.91E+3nMAssay Description:Binding affinity towards human Alpha-1A adrenergic receptor by the displacement of [3H]prazosinMore data for this Ligand-Target Pair
In DepthDetails
TargetAmine oxidase [flavin-containing] A/B(Homo sapiens (Human))
Universit£ Louis Pasteur

Curated by ChEMBL
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]idazoxan from I2 imidazoline binding sites (I2Bs) of rabbit renal cortex membranesMore data for this Ligand-Target Pair
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataKi:  2.14E+4nMAssay Description:Binding affinity towards human Alpha-1B adrenergic receptor by the displacement of [3H]prazosinMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataEC50:  724nMAssay Description:Agonistic activity towards human Alpha-2B adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataEC50:  191nMAssay Description:Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataEC50:  275nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Show SMILES C1CC1C(NC1=NCCO1)C1CC1
Show InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
Affinity DataEC50:  178nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair