BDBM50092760 CHEMBL3586312

SMILES COc1cc(cc2CN(Cc3cncnc3)CCOc12)-c1csc2ccccc12

InChI Key InChIKey=AJKCXWJAJVDPNV-UYAOXDASSA-N

Data  2 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50092760   

TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50092760(CHEMBL3586312)
Show SMILES COc1cc(cc2CN(Cc3cncnc3)CCOc12)-c1csc2ccccc12
Show InChI InChI=1S/C21H25FN2/c1-16-13-19(22)7-8-21(16)24-11-9-23(10-12-24)15-18-14-20(18)17-5-3-2-4-6-17/h2-8,13,18,20H,9-12,14-15H2,1H3/t18-,20-/m1/s1
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50092760(CHEMBL3586312)
Show SMILES COc1cc(cc2CN(Cc3cncnc3)CCOc12)-c1csc2ccccc12
Show InChI InChI=1S/C21H25FN2/c1-16-13-19(22)7-8-21(16)24-11-9-23(10-12-24)15-18-14-20(18)17-5-3-2-4-6-17/h2-8,13,18,20H,9-12,14-15H2,1H3/t18-,20-/m1/s1
Affinity DataIC50: 80nMAssay Description:Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionMore data for this Ligand-Target Pair