BDBM50099737 2-Amino-phenanthrene-9,10-dione::CHEMBL417727::US9073941, 902::cid_254021

SMILES Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21

InChI Key InChIKey=HENHQTJCDFNZOI-UHFFFAOYSA-N

Data  29 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50099737   

TargetFocal adhesion kinase 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50: >7.00E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCathepsin S(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory concentration against Cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University Of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataEC50: >5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University Of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  5.90E+3nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University Of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataEC50: >5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  4.54E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50: >6.95E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMannose-6-phosphate isomerase(Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  5.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetG-protein coupled receptor 55(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  1.36E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDNA damage-inducible transcript 3 protein(Mus musculus)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  5.06E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetX-box-binding protein 1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  1.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDNA damage-inducible transcript 3 protein(Mus musculus)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  5.06E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCysteine protease ATG4B(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  1.56E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPhospholipase A2(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  4.88E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetApoptotic protease-activating factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  768nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetApoptotic protease-activating factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50: >1.00E+5nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-9(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  643nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitochondrial peptide methionine sulfoxide reductase(Bos taurus)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataEC50:  9.09E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  5.14E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProtein artemis(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  630nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  1.34E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDihydrolipoyl dehydrogenase(Mycobacterium tuberculosis)
Academia Sinica

US Patent
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  670nMpH: 7.0Assay Description:The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (2010) 49:1616-1627 and modified for an online robotics sc...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  788nMpH: 7.0Assay Description:Mtb PDH (Lpd+DlaT+AceE) is provided by Dr. Bryk Ruslana. The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  600nMAssay Description:Inhibitory concentration against Cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 13(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory concentration against FAP-1 using lck-10mer as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory concentration against PTP1B lusing lck-10mer as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against Cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory concentration against CD45 protein-tyrosine phosphatase using lck-10mer as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 13(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibitory concentration against FAP-1 using pNPP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMothers against decapentaplegic homolog 3(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  9.89E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: F.M. Hoffmann, University ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay