BDBM50400034 FOSTAMATINIB DISODIUM::R788 SODIUM::R935788 SODIUM

SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP([O-])([O-])=O)c4n3)n2)cc(OC)c1OC

InChI Key InChIKey=GKDRMWXFWHEQQT-UHFFFAOYSA-L

Data  1 IC50  1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50400034   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50400034(FOSTAMATINIB DISODIUM | R788 SODIUM | R935788 SODI...)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP([O-])([O-])=O)c4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)/p-2
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant spleen tyrosine kinase (360 to 635 amino acid residues) after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50400034(FOSTAMATINIB DISODIUM | R788 SODIUM | R935788 SODI...)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP([O-])([O-])=O)c4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)/p-2
Affinity DataKd:  70nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair