BDBM50468271 CHEMBL4290134

SMILES CC(C)(C)c1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1

InChI Key InChIKey=QTABKBZRAZXDQK-UHFFFAOYSA-N

Data  5 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50468271   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50468271(CHEMBL4290134)
Affinity DataIC50:  5nMAssay Description:Inhibition of human TNKS1 (1030 to 1317 residues) by fluorescence based activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50468271(CHEMBL4290134)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full-length Myc/His-tagged Parp-1 expressed in baculovirus infected Sf21 insect cells assessed as reduction in auto-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50468271(CHEMBL4290134)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant full length TNKS1 (1030 to 1317 residues) expressed in Escherichia coli assessed as inhibition by fluorescence based ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50468271(CHEMBL4290134)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50468271(CHEMBL4290134)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50468271(CHEMBL4290134)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of tankyrase 1/2 in human DLD1 cells assessed as increase in axin2 accumulation incubated for 24 hrs by luminex based bead assayMore data for this Ligand-Target Pair