BDBM9441 CHEMBL1082738::Heterodimeric Tacrine-Based Inhibitor 8g::N-4-Quinolyl-N-9-(1,2,3,4-tetrahydroacridinyl)-1,8-diaminooctane Hydrochloride Salt::N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl]quinolin-4-amine trihydrochloride

SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1ccnc2ccccc12

InChI Key InChIKey=UNVOAAWEEGAXTN-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 9441   

TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM9441(CHEMBL1082738 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1ccnc2ccccc12
Show InChI InChI=1S/C30H36N4/c1(3-11-20-31-27-19-22-32-26-16-8-5-13-23(26)27)2-4-12-21-33-30-24-14-6-9-17-28(24)34-29-18-10-7-15-25(29)30/h5-6,8-9,13-14,16-17,19,22H,1-4,7,10-12,15,18,20-21H2,(H,31,32)(H,33,34)
Affinity DataIC50: 8.80nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM9441(CHEMBL1082738 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1ccnc2ccccc12
Show InChI InChI=1S/C30H36N4/c1(3-11-20-31-27-19-22-32-26-16-8-5-13-23(26)27)2-4-12-21-33-30-24-14-6-9-17-28(24)34-29-18-10-7-15-25(29)30/h5-6,8-9,13-14,16-17,19,22H,1-4,7,10-12,15,18,20-21H2,(H,31,32)(H,33,34)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM9441(CHEMBL1082738 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1ccnc2ccccc12
Show InChI InChI=1S/C30H36N4/c1(3-11-20-31-27-19-22-32-26-16-8-5-13-23(26)27)2-4-12-21-33-30-24-14-6-9-17-28(24)34-29-18-10-7-15-25(29)30/h5-6,8-9,13-14,16-17,19,22H,1-4,7,10-12,15,18,20-21H2,(H,31,32)(H,33,34)
Affinity DataIC50: 126nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair