BDBM26265 (5S)-6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate::ESZ::Estorra::Eszopiclone::Lunesta::cid_5735

SMILES: CN1CCN(CC1)C(=O)Oc1n(-c2ccc(Cl)cn2)c(=O)c2ncc[nH]c12

InChI Key: InChIKey=DZCUZLPTNNFSNM-UHFFFAOYSA-N

Data: 28 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 26265   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sphingosine 1-phosphate receptor 3 (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [T206C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		0.830	-12.4	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-200],P14867[176-456] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		22.4	-10.4	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [T162C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		33.8	-10.2	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [S205C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		34.9	-10.2	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,L179C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		46.3	-10.0	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		50.1	-9.85	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [S204C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		57.9	-9.87	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [A160C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		60.4	-9.84	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [V211C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		62.4	-9.82	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,R233C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		67	-9.78	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,R224C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		70.9	-9.75	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,T165C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		71.9	-9.74	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,T120C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		75.2	-9.71	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,D95C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		82.4	-9.66	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		102	-9.44	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,M169C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		102	-9.53	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,R171C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		110	-9.49	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2 [29-451]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		114	-9.37	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [G200C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		119	-9.44	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3 [29-492]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		162	-9.16	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,R183C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		174	-9.21	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [V202C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		249	-9.00	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,A118C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		393	-8.73	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [F99C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		407	-8.62	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,T181C] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		503	-8.59	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [G157C]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		2.10E+3	-7.74	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-6 [20-453]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.50E+4	>-6.51	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-4 [36-554]/beta-2 [26-512]/gamma-2 [40-467] (Human)	BDBM26265 (ESZ | Estorra | cid_5735 | (5S)-6-(5-chloropyridin...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.50E+4	>-6.51	n/a	n/a	n/a	n/a	n/a	7.4	22
TBA									Citation and Details
					More data for this Ligand-Target Pair