BDBM50399540 FORETINIB::US10464902, Foretinib::US10882853, Compound For-Oxide::US20250129067, Compound Foretinib

SMILES: COc1cc2c(ccnc2cc1OCCCN3CCOCC3)Oc4ccc(cc4F)NC(=O)C5(CC5)C(=O)Nc6ccc(cc6)F

InChI Key: InChIKey=CXQHYVUVSFXTMY-UHFFFAOYSA-N

Data: 8 KI  176 IC50  8 Kd

PDB links: 5 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 192 hits for monomerid = 50399540   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.89	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [1-973] (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.72	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.61	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha [1-973] (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.78	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.86	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-973] (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.99E+3	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.52	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.89	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.91	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.860	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair