BDBM50247054 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-methylnicotinamide::CHEMBL517140::GSK-189254

SMILES: CNC(=O)c1ccc(Oc2ccc3CCN(CCc3c2)C2CCC2)nc1

InChI Key: InChIKey=WROHEWWOCPRMIA-UHFFFAOYSA-N

Data: 8 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50247054   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Human)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Human)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Human)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		0.126	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Human)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rat)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		0.631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rat)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		0.676	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rat)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H1 receptor (Human)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		>2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H2 receptor (Human)	BDBM50247054 (GSK-189254 | 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H...) Show SMILES Show InChI	GoogleScholar	UniChem		>3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair