BDBM18069 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine::CHEMBL22::TMP::Trimethoprim::Trimethoprim (TMP)::US10870625, Compound TMP

SMILES: COc1cc(cc(c1OC)OC)Cc2cnc(nc2N)N

InChI Key: InChIKey=IEDVJHCEMCRBQM-UHFFFAOYSA-N

Data: 55 KI  226 IC50  1 EC50

PDB links: 28 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 280 hits for monomerid = 18069   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Bacillus anthracis)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.73E+4	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.62E+6	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mycobacterium avium)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.75E+3	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli (strain K12))	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Staphylococcus aureus)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	75	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	7.0	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mycobacterium avium)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli (strain K12))	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mycobacterium avium)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rat)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium parvum)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG...)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli (strain K12))	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bacillus anthracis)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a	7.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli (strain K12))	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40E+5	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Yeast)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Staphylococcus aureus)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Staphylococcus aureus)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase type 1 from Tn4003 (Staphylococcus aureus)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Staphylococcus aureus)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 2 (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 4 (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 3 (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human pneumocystis pneumonia agent)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Escherichia coli)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Cryptosporidium parvum)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18069 (CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair