BDBM12192 (2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoindol-2-yl)ethan-1-one::US11096924, DASH-inhibitors 3360::US11559537, Compound 3360-C::isoquinoline derivative 15

SMILES N[C@@H](C1CCCCC1)C(=O)N1Cc2ccccc2C1

InChI Key InChIKey=SUSVSQMWKFICCC-HNNXBMFYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 12192   

TargetDipeptidyl peptidase 8(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  24nMpH: 8.0 T: 2°CAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  1.50E+4nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  1.65E+4nMAssay Description:The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  5.00E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  4.60E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  130nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  1.30E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  5nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees Of Tufts College

US Patent
LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  4.60nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  1.38E+3nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
National Health Research Institutes

LigandPNGBDBM12192((2S)-2-amino-2-cyclohexyl-1-(2,3-dihydro-1H-isoind...)
Affinity DataIC50:  1.38E+6nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent