BDBM176223 US10047103, 256::US9688695, 256

SMILES COc1cc(OCc2csc(NCC3CCCO3)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1

InChI Key InChIKey=CKPKXLBOVYLIRO-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176223   

TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176223(US10047103, 256 | US9688695, 256)
Affinity DataEC50:  7.80nMT: 2°CAssay Description:Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176223(US10047103, 256 | US9688695, 256)
Affinity DataIC50: >3.00E+3nMT: 2°CAssay Description:The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176223(US10047103, 256 | US9688695, 256)
Affinity DataEC50:  7.80nMT: 2°CAssay Description:The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM176223(US10047103, 256 | US9688695, 256)
Affinity DataEC50: >3.00E+3nMT: 2°CAssay Description:Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated for 5 minutes at room temperature with varying concentrations of compounds...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent