BDBM18438 4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide::NCGC00060210::Sulfonamide analogue, 2

SMILES CCc1nnc(NC(=O)c2ccc(NS(=O)(=O)c3ccccc3)cc2)s1

InChI Key InChIKey=YMGXUJCEBOCIIT-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18438   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nih

LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)
Affinity DataKi:  52nM ΔG°:  -9.80kcal/mole IC50:  103nMpH: 5.9 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent resorufin from the substrate. The fluorescence was measured (excitation 570 nm, emiss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nih

LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nih

LigandPNGBDBM18438(4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed