BDBM20504 1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea::BMCL163287 Compound 15::SB-705498
SMILES FC(F)(F)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
InChI Key InChIKey=JYILLRHXRVTRSH-GFCCVEGCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 20504
Affinity DataEC50: 32nMpH: 7.2 T: 2°CAssay Description:One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Neurogen
Curated by ChEMBL
Neurogen
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of rat TRPV1More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Henan University
Curated by ChEMBL
Henan University
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity against human TRPM8 expressed in HEK293 cells assessed as inhibition of methanol-gated currents by whole cell patch clamp electro...More data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced Ca2+ influx incubated for 30 mins by FLIPR meth...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]RTX from human TRPV1 expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair