BDBM223395 US9315520, 1::US9315520, Comparator 1::US9315520, Example 1::US9315520, Example 2::US9605007, Example 1

SMILES: C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1

InChI Key: InChIKey=ZLZUHACSRMOLLV-UHFFFAOYSA-N

Data: 20 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 223395   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
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Cathepsin D (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>9.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 2 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	194	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 2 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.36E+4	n/a	n/a	n/a	n/a	n/a	37
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					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	n/a	37
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Cytochrome P450 2D6 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Isoform D of Beta-secretase 1 (BACE-I-432) (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	4.5	37
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					More data for this Ligand-Target Pair
Isoform D of Beta-secretase 1 (BACE-I-432) (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	4.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isoform D of Beta-secretase 1 (BACE-I-432) (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	4.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM223395 (US9315520, Example 1 | US9315520, Comparator 1 | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair