BDBM24498 3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-1-(2-phenylacetyl)thiourea::CHEMBL254760::US10464902, MGCD-265::thieno[3,2-b]pyridine-based inhibitor, 10a

SMILES: Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1

InChI Key: InChIKey=UFICVEHDQUKCEA-UHFFFAOYSA-N

Data: 2 KI  10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 24498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	7.5	30
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Vascular endothelial growth factor receptor 2 (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte growth factor receptor (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Smoothened homolog (Human)	BDBM24498 (CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem		42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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