BDBM246853 4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,1'H-4,4'- bipyrazol-1- yl)azetidin-1-yl]-2,5- difluoro-N-[(1S)- 2,2,2-trifluoro-1- methylethyl] benzamide::US10053465, 2::US10065963, Compound 2::US10125150, Example 2::US10336759, # 2::US10435392, Example 17::US10479803, Example 2D::US10519163, Example 2::US10675284, Example 2::US11084822, Example 2::US11130767, # 2::US11136326, Example 2::US11304949, Compound 4::US11324749, Comp. No. 4::US11591318, Example 7::US11596632, Comp. No. 4::US11918581, Compound 4::US11957661, Compound 1::US11992490, Compound 4::US20240058343, Compound 4::US20240307353, Compound 1::US9732097, Example 2::US9926301, Example 17

SMILES: C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F

InChI Key: InChIKey=MSGYSFWCPOBHEV-UHFFFAOYSA-N

Data: 54 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 57 hits for monomerid = 246853   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	250	n/a	n/a	n/a	n/a	6.7	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<2.00E+3	n/a	n/a	n/a	n/a	7.8	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	6.7	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	6.7	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	6.7	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	250	n/a	n/a	n/a	n/a	6.7	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132] (Human)	BDBM246853 (4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair