BDBM25474 JMC516642 Compound 5::N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl}-2,3-dihydro-1,4-benzodioxine-2-carboxamide::SR3677

SMILES: CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccccc2O1)-c1cn[nH]c1

InChI Key: InChIKey=OQWZIAVXCYIZNN-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 25474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 [1-543,T431N] (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.0	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.97E+3	n/a	n/a	n/a	n/a	7.3	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase MRCK alpha (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	7.3	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.49E+3	n/a	n/a	n/a	n/a	7.3	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM25474 (N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair