BDBM263508 (r)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(2-phenylpropyl)acetamide::US10561662, Example 80::US11173161, EX 80::US9556130, test 80
SMILES C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1
InChI Key InChIKey=NHHIFMSLOXYVBO-ZDUSSCGKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 263508
Affinity DataKi: 4.45E+3nM ΔG°: -6.78kcal/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Affinity DataKi: 4.45E+3nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
Affinity DataKi: 4.45E+3nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
Affinity DataKi: 4.45E+6nMAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Affinity DataEC50: 288nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair