BDBM26392 2,4-diamino-5,6-disubstituted pyrimidine, 6::6-(4-methylpiperazin-1-yl)-3,5-diazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2,4,6,10,12-hexaen-4-amine

SMILES CN1CCN(CC1)c1nc(N)nc-2c1CCc1ccccc-21

InChI Key InChIKey=CEUMRIVIGREJGB-UHFFFAOYSA-N

Data  6 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 26392   

TargetHistamine H4 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  5.40nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  15.5nM ΔG°:  -10.6kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  186nMAssay Description:Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  9.12E+3nMAssay Description:Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  9.77E+3nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human histamine 3 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataKi:  3.16E+4nMAssay Description:Displacement of [3H]UR-DE257 from human histamine 2 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26392(2,4-diamino-5,6-disubstituted pyrimidine, 6 | 6-(4...)
Affinity DataEC50:  295nMAssay Description:Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed