BDBM277390 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile::US10072026, Example 1::US10947254, Example 1-18::US11780852, Example 1-2

SMILES: Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CCC#N)n2)n[nH]1

InChI Key: InChIKey=DADAEARVGOQWHV-UHFFFAOYSA-N

Data: 20 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 277390   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		0.550	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM277390 (US10072026, Example 1 | 3-((1R,3s,5S)-3-((7-((5-me...) Show SMILES Show InChI	GoogleScholar	UniChem		50.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair