BDBM27951 2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl}phenyl)bicyclo[2.2.2]octan-1-yl]propanoic acid::bicyclo[2.2.2]octane-pyrimido[4,5-b][1,4]oxazine deriv., 5

SMILES CC(C(O)=O)C12CCC(CC1)(CC2)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C

InChI Key InChIKey=SDCTVTHMLSAULR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27951   

TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM27951(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Affinity DataIC50:  1.80E+4nMpH: 7.4 T: 2°CAssay Description:The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM27951(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed