BDBM28986 N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl}trifluoromethanesulfonamide::cyclohexyl sulfone-based compound, 32

SMILES: c1cc(ccc1S(=O)(=O)C2(CCC(CC2)NS(=O)(=O)C(F)(F)F)c3cc(ccc3F)F)Cl

InChI Key: InChIKey=WDZVWDXOIGQJIO-UHFFFAOYSA-N

Data: 10 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 28986   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.650	n/a	n/a	n/a	n/a
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Presenilin-1 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
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Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
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Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Human)	BDBM28986 (N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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