BDBM3567 CHEMBL328106::N-(4-bromophenyl)-6,7-dimethoxyquinazolin-4-amine::PD153035 Analog 67

SMILES COc1cc2ncnc(Nc3ccc(Br)cc3)c2cc1OC

InChI Key InChIKey=MCNVTWIIWNZMGB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3567   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3567(CHEMBL328106 | N-(4-bromophenyl)-6,7-dimethoxyquin...)
Affinity DataIC50:  0.960nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM3567(CHEMBL328106 | N-(4-bromophenyl)-6,7-dimethoxyquin...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3567(CHEMBL328106 | N-(4-bromophenyl)-6,7-dimethoxyquin...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3567(CHEMBL328106 | N-(4-bromophenyl)-6,7-dimethoxyquin...)
Affinity DataIC50:  0.0724nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed