BDBM4891 3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid::3-[4-Methyl-5-(2-oxo-6-phenyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic Acid::3-substituted indolin-2-one 11e::SU5402 analog 11e

SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2cc(ccc12)-c1ccccc1

InChI Key InChIKey=CEFJMJRPRONXNH-UNOMPAQXSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4891   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sugen

LigandPNGBDBM4891(3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

LigandPNGBDBM4891(3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H...)
Affinity DataIC50: >1.00E+5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

LigandPNGBDBM4891(3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H...)
Affinity DataIC50:  160nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Sugen

LigandPNGBDBM4891(3-(4-methyl-5-{[(3Z)-2-oxo-6-phenyl-2,3-dihydro-1H...)
Affinity DataIC50:  1.05E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed